Semaglutide dose guide

Semaglutide dosage

A GLP-1 receptor agonist that mimics a gut hormone your body releases after eating: it reduces appetite and slows stomach emptying. Commonly reported: the constant background thoughts about food ("food noise") go quiet and portions shrink without effort, with nausea worst in the first days after each dose step. FDA-approved for type 2 diabetes, weight management, heart-risk reduction and MASH, with about 15% average weight loss at 68 weeks in its main trial.

Dose range

0.25–2.4 mg (fda label).

How often

Weekly: Weekly SubQ

A typical run

Ongoing. FDA-approved for ongoing use. Community uses indefinitely or until goal weight reached, then tapers.

How it’s taken

Vial: SubQ injection

Evidence

Established: Clinical trials or FDA-approved use exists

Half-life

~1 week (FDA label)

Semaglutide on your syringe

With a 10 mg vial and 2 mL of water (5 mg in every mL), on a 0.5 mL (50-unit) U-100 insulin syringe: the low end, 0.25 mg, is 5 units; and the high end, 2.4 mg, is 48 units. 40 doses in the vial at the low end. All U-100: 100 units to the mL. A U-40 syringe reads differently.

What to take alongside each peptideSemaglutide in the peptide libraryThe Dose Guide: every peptide

More glp-1 & metabolic peptides

• Semaglutide (oral) 1.5–25 mg
• Tirzepatide 2.5–15 mg
• Retatrutide 1–12 mg
• Liraglutide 0.6–3 mg
• Dulaglutide 0.75–4.5 mg
• Orforglipron 0.8–17.2 mg
• Survodutide 0.3–6 mg
• Mazdutide 2–6 mg
• Pemvidutide 1.2–2.4 mg
• Cagrilintide 0.25–2.4 mg
• CagriSema 0.25–2.4 mg
• 5-Amino-1MQ 50–100 mg
• SLU-PP-332 250–1000 mcg
• Oxytocin 10–40 IU

A community reference, not medical advice. Each range is what has been studied or is commonly run, never a dose for you.