Oxytocin dose guide

Oxytocin dosage

Best known as the "bonding hormone," oxytocin is a hypothalamic neuropeptide with broader effects than most people realize. As a nasal spray, single doses have cut how much people eat at a meal and blunted stress responses in small studies, though an 8-week trial didn't produce weight loss; anti-inflammatory effects come mostly from animal work. Commonly reported: a subtle calm, warm or more connected feeling shortly after a spray, and for many, little or inconsistent effect from dose to dose. FDA-approved only as an obstetric injection (Pitocin).

Dose range

10–40 IU (research range). Studied in research — not a recommendation.

How often

1–2× daily: 1–2x daily or as needed

A typical run

As-needed use most common. Animal studies suggest tolerance with frequent daily use, so many users cycle or use it situationally.

How it’s taken

Nasal spray: Intranasal

Evidence

Moderate: Animal studies + some human data

Half-life

~1–6 min (in blood; nasal doses peak in blood at ~15 min)

Oxytocin on your syringe

Used as a nasal spray, so it’s dosed by sprays, not drawn into a syringe.

Oxytocin in the peptide libraryThe Dose Guide: every peptide

More glp-1 & metabolic peptides

• Semaglutide 0.25–2.4 mg
• Semaglutide (oral) 1.5–25 mg
• Tirzepatide 2.5–15 mg
• Retatrutide 1–12 mg
• Liraglutide 0.6–3 mg
• Dulaglutide 0.75–4.5 mg
• Orforglipron 0.8–17.2 mg
• Survodutide 0.3–6 mg
• Mazdutide 2–6 mg
• Pemvidutide 1.2–2.4 mg
• Cagrilintide 0.25–2.4 mg
• CagriSema 0.25–2.4 mg
• 5-Amino-1MQ 50–100 mg
• SLU-PP-332 250–1000 mcg

A community reference, not medical advice. Each range is what has been studied or is commonly run, never a dose for you.