Tirzepatide dose guide

Tirzepatide dosage

The first dual GIP/GLP-1 receptor agonist: it activates two gut-hormone pathways at once, and in a head-to-head trial it produced more weight loss than semaglutide (20.2% vs 13.7% at 72 weeks). Commonly reported: very strong appetite suppression and meals ending early, with nausea or tiredness for a day or two after the injection, mostly after dose increases. FDA-approved for diabetes (Mounjaro) and for weight management and sleep apnea (Zepbound).

Dose range

2.5–15 mg (fda label).

How often

Weekly

A typical run

Ongoing. FDA-approved for ongoing use. Titrate slowly upward. Community maintains on minimum effective dose.

How it’s taken

Vial: SubQ injection

Evidence

Established: Clinical trials or FDA-approved use exists

Half-life

~5 days (FDA label)

Tirzepatide on your syringe

With a 10 mg vial and 2 mL of water (5 mg in every mL), on a 1 mL (100-unit) U-100 insulin syringe: the low end, 2.5 mg, is 50 units; and the high end, 15 mg, needs more than this vial holds. 4 doses in the vial at the low end. All U-100: 100 units to the mL. A U-40 syringe reads differently.

How to reconstitute tirzepatideRetatrutide week by weekWhat to take alongside each peptideTirzepatide in the peptide libraryThe Dose Guide: every peptide

More glp-1 & metabolic peptides

• Semaglutide 0.25–2.4 mg
• Semaglutide (oral) 1.5–25 mg
• Retatrutide 1–12 mg
• Liraglutide 0.6–3 mg
• Dulaglutide 0.75–4.5 mg
• Orforglipron 0.8–17.2 mg
• Survodutide 0.3–6 mg
• Mazdutide 2–6 mg
• Pemvidutide 1.2–2.4 mg
• Cagrilintide 0.25–2.4 mg
• CagriSema 0.25–2.4 mg
• 5-Amino-1MQ 50–100 mg
• SLU-PP-332 250–1000 mcg
• Oxytocin 10–40 IU

A community reference, not medical advice. Each range is what has been studied or is commonly run, never a dose for you.