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TB-500 Fragment — dosage, half-life & reference guide

Healing & recovery peptide · also known as TB-4 Frag, Thymosin Beta-4 Fragment, Ac-SDKP

An isolated fragment of TB-500 (specifically the Ac-SDKP tetrapeptide from its N-terminal). This fragment provides more targeted action on tendons, ligaments, and connective tissue than full TB-500, with anti-inflammatory and angiogenic properties. Preferred by some for focused tendon and ligament repair work rather than systemic healing.

Commonly-researched dose ranges

TB-500 Fragment is commonly researched at 250–750 mcg, eod or twice weekly., by SubQ injection. These are reference ranges from the literature and community use, not a prescription.

Half-life

Estimated half-life: ~2-4 hours. See how it accumulates in the half-life calculator.

Safety & interactions

Commonly reported effects: injection site reaction, fatigue, headache. Discuss with your clinician.

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