Ac-SDKP Dosage, half-life & reference guide
Also known as TB-500 Fragment · TB-4 Frag · Goralatide · Thymosin Beta-4 (1-4)
The first four amino acids of thymosin beta-4, sold as a 'TB-500 fragment' though it isn't part of TB-500. In rodent studies it calms inflammation and scarring in the heart, kidneys and lungs and helps new blood vessels form; no study has looked at tendons or ligaments.
- Studied range
- 250–750 mcg
- How often
- EOD
- Half-life
- ~4.5 min
- Evidence
- ●
●●Emerging - Route
- SubQ injection
Studied in research — not a recommendation.
How it works.
Isolated N-terminal tetrapeptide of Thymosin Beta-4, residues 1–4; TB-500 itself is residues 17–23, so this isn't part of TB-500. In rodent and cell studies it is anti-inflammatory and anti-fibrotic in heart, kidney and lung models and promotes angiogenesis and cell migration. It is cleared by ACE within minutes, and ACE inhibitors raise its blood levels about fourfold.
Commonly reported: Community data are sparse, and users who report on it describe it much like TB-500, a gradual easing of soft-tissue aches.
Half-life & active level
The half-life of Ac-SDKP is ~4.5 min (measured in healthy volunteers after IV; cleared by ACE, and a SubQ dose peaks in about 15 minutes).
Here's how a typical Ac-SDKP schedule plays out over 48 hours (one-compartment estimate).
An estimate from the half-life above, not a measurement. See your own curve build live in the half-life calculator.
Where Ac-SDKP works.
Heart & blood vessels
In animals. In rodent studies it calms inflammation and scarring in the heart, kidneys and lungs and helps new blood vessels form.
Joints & tendons
Reported by users. Users who report on it describe it much like TB-500, a gradual easing of soft-tissue aches.
An area lights for what a peptide is used for and what people report, with the evidence beside it. It isn’t a promise that it works there.
Mixing and a typical run.
Example numbers
Reconstitution example
Reconstitute a 5 mg vial of Ac-SDKP with 2 mL of bacteriostatic water and a 500 mcg dose is 20 units on a U-100 syringe, about 10 doses per vial.
- Vial
- 5 mg
- Water
- 2 mL
- Amount
- 500 mcg
Draw to20 units
0.3 mL insulin syringe · 30 units
Run notes
- Cycle
- 6-8 week cycles typical. Preferred over full TB-500 by some for targeted tendon/ligament work.Community practice — opinions vary. Not a clinical recommendation.
- Timing
- SubQ near area of injury or rotate standard sites. Timing flexible.
- Route
- SubQ injection
- Stacks
- BPC-157, TB-500, GHK-Cu
Safety.
Common side effects
- Injection site reaction
- Fatigue
- Headache
Questions people ask.
What is Ac-SDKP?
The first four amino acids of thymosin beta-4, sold as a 'TB-500 fragment' though it isn't part of TB-500. In rodent studies it calms inflammation and scarring in the heart, kidneys and lungs and helps new blood vessels form; no study has looked at tendons or ligaments.
How is Ac-SDKP dosed in research?
The research range for Ac-SDKP is 250–750 mcg, EOD or twice weekly. Studied in research — not a recommendation.
How long does Ac-SDKP last?
The half-life of Ac-SDKP is ~4.5 min (measured in healthy volunteers after IV; cleared by ACE, and a SubQ dose peaks in about 15 minutes).
What do people report on Ac-SDKP?
Commonly reported on Ac-SDKP: community data are sparse, and users who report on it describe it much like TB-500, a gradual easing of soft-tissue aches.
Is Ac-SDKP safe?
The research basis for Ac-SDKP is emerging: primarily preclinical / limited human data. Common side effects in the library: injection site reaction, fatigue and headache.
What does Ac-SDKP stack with?
Common stacks for Ac-SDKP: BPC-157, TB-500 and GHK-Cu.
Research.
Reference.
- Cadence
EOD
EOD or twice weekly.
- Half-life
~4.5 min
~4.5 min (measured in healthy volunteers after IV; cleared by ACE, and a SubQ dose peaks in about 15 minutes)
- Research basis
●
●●EmergingPrimarily preclinical / limited human data
PepVault for iPhone
Track Ac-SDKP in PepVault
Log every dose, keep your vial and the doses left in it and watch its estimated active level. 7 days free on the yearly plan for new subscribers.
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