Larazotide — dosage, half-life & reference guide

Healing & recovery peptide · also known as AT-1001, Larazotide Acetate

A tight junction regulator that targets gut permeability directly. Larazotide works by blocking the zonulin pathway, which controls the 'gates' between cells in your intestinal lining. When those gates open too much (leaky gut), inflammation follows. One of the few gut peptides with Phase 2 clinical trial data.

Commonly-researched dose ranges

Larazotide is commonly researched at 0.5–1 mg, 3x daily with meals, by Oral. These are reference ranges from the literature and community use, not a prescription.

Half-life

Estimated half-life: Very short (local gut action). See how it accumulates in the half-life calculator.

Safety & interactions

Commonly reported effects: generally well tolerated, mild gi upset, nausea. Discuss with your clinician.

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