MK-677 dose guide

MK-677 dosage

Not actually a peptide — it's a small molecule you take orally that mimics ghrelin to stimulate GH release. The convenience of a daily pill instead of injections makes it popular. Commonly reported: strong hunger, especially in the first weeks; water retention with puffy hands and feet or tingling hands; and deeper sleep with vivid dreams, sometimes with morning grogginess. Once-daily dosing boosts natural GH pulses and keeps IGF-1 elevated.

Dose range

10–25 mg (research range). Studied in research — not a recommendation.

How often

Daily: Daily, before bed

A typical run

8–16 weeks. Continuous use common (oral convenience). Some cycle 3 months on / 1 month off. Long-term safety data limited.

How it’s taken

Taken by mouth: Oral

Evidence

Moderate: Animal studies + some human data

Half-life

~24 hours (community estimate; no half-life has been published for people: in dogs it was 4–6 hours, and its effect on GH and IGF-1 lasts about a day)

MK-677 on your syringe

Taken by mouth, so there’s nothing to draw.

MK-677 in the peptide libraryThe Dose Guide: every peptide

More growth hormone peptides

• Ipamorelin 200–300 mcg
• CJC-1295 with DAC 1–2 mg
• CJC-1295 no DAC 100–200 mcg
• Sermorelin 200–500 mcg
• Tesamorelin 1–2 mg
• GHRP-2 100–300 mcg
• GHRP-6 100–300 mcg
• Hexarelin 100–200 mcg
• Fragment 176-191 250–500 mcg
• IGF-1 LR3 20–50 mcg
• PEG-MGF 200–400 mcg
• Follistatin-344 100–200 mcg
• HGH 1–4 IU

A community reference, not medical advice. Each range is what has been studied or is commonly run, never a dose for you.