PEG-MGF dose guide

PEG-MGF dosage

When muscle is loaded or damaged, the IGF-1 gene can be read a different way, producing a variant with an extra tail. That tail — 24 amino acids, cut off during processing — is mechano growth factor, which its discoverers found tells muscle stem cells to multiply before they commit to repair. PEG-MGF is the same tail with polyethylene glycol attached to make it last longer in the body. Commonly reported: very little you can feel, sometimes local soreness or fullness, which fits a peptide with no systemic signal to give. Its cell evidence is genuinely disputed: the group that discovered the effect and two drug companies that tried to repeat it reached opposite results.

Dose range

200–400 mcg (research range). Studied in research — not a recommendation.

How often

2–3× weekly: 2–3x weekly, post-workout

A typical run

8–16 weeks per community cycle. Community cycles commonly run 8 to 16 weeks with about a 4-week break, often with a stepped-up loading phase at the start; none of that comes from a study. The animal experiments were single or short courses of locally delivered peptide, mostly within days of an injury.

How it’s taken

Vial: SubQ injection, IM injection

Evidence

Emerging: Primarily preclinical / limited human data

Half-life

Not measured: no pharmacokinetic study of PEG-MGF has been published, in people or in animals. The unmodified peptide is broken down quickly, and for a mouse heart study researchers stabilized it chemically — amidating one end and swapping two arginines for their mirror-image form (Mavrommatis 2013); attaching PEG is a standard way to slow that clearance. The 48-to-72-hour figure community guides quote has never been measured.

PEG-MGF on your syringe

With a 5 mg vial and 2 mL of water (2.5 mg in every mL), on a 0.3 mL (30-unit) U-100 insulin syringe: the low end, 200 mcg, is 8 units; and the high end, 400 mcg, is 16 units. 25 doses in the vial at the low end. All U-100: 100 units to the mL. A U-40 syringe reads differently.

PEG-MGF in the peptide libraryThe Dose Guide: every peptide

More growth hormone peptides

• Ipamorelin 200–300 mcg
• CJC-1295 with DAC 1–2 mg
• CJC-1295 no DAC 100–200 mcg
• Sermorelin 200–500 mcg
• Tesamorelin 1–2 mg
• GHRP-2 100–300 mcg
• GHRP-6 100–300 mcg
• Hexarelin 100–200 mcg
• MK-677 10–25 mg
• Fragment 176-191 250–500 mcg
• IGF-1 LR3 20–50 mcg
• Follistatin-344 100–200 mcg
• HGH 1–4 IU

A community reference, not medical advice. Each range is what has been studied or is commonly run, never a dose for you.