Selank Dosage, half-life & reference guide
Also known as Tuftsin analogue · TP-7
A synthetic peptide based on tuftsin, an immune molecule your spleen naturally produces. In small Russian trials it eased anxiety about as well as benzodiazepine comparators, and no dependence has been reported, though it hasn't been formally studied. In rats it modulated GABA receptors and raised BDNF (a brain growth factor).
- Studied range
- 250–500 mcg
- How often
- Daily
- Half-life
- ~10 min in blood
- Evidence
- ●●
●Moderate - Routes
- Nasal spray, SubQ
Studied in research — not a recommendation.
How it works.
Synthetic analogue of the immunomodulatory peptide Tuftsin. Its anxiolytic and nootropic effects run through GABA and serotonin systems (rat studies). Reduced anxiety without sedation in small Russian trials; memory and learning gains come from rodent studies.
Commonly reported: Calmer and less socially tense without feeling sedated, subtle effects for some, and mild tiredness at higher doses. Approved as an anxiety medication in Russia.
Where Selank works.
Brain, nerves & sleep
In people. In small Russian trials it eased anxiety about as well as benzodiazepine comparators.
An area lights for what a peptide is used for and what people report, with the evidence beside it. It isn’t a promise that it works there.
Week by week.
What to expect in the first 8 weeks
- Onset
- Hours
- Peak effect
- 2–4 weeks
- Duration
- 10–21 days
Day 1–3Community
Calm without the fog
Commonly reported: Selank works fast, often within the first dose, with a noticeable calm that doesn't bring drowsiness or mental blunting. Social anxiety, rumination and that background hum of stress tend to ease; for some the effect is subtle.
The science
In rats, Selank changed GABA-A receptor gene expression (Volkova 2016), which produces an anxiolytic effect similar to benzodiazepines without their sedation. It also inhibits the enzymes that break down enkephalins (Zozulya 2001).
Sources- Volkova et al. (2016)
- Zozulya et al. (2001)
Updated Sep 2026
Day 3–7Community
Stress resilience is building
Commonly reported this week: a smoother stress response, with things that would normally spike your anxiety feeling more manageable. In rats, Selank raises BDNF, the growth factor that exercise and antidepressants both boost.
The science
Selank raised BDNF expression in the rat hippocampus (Inozemtseva 2008). Small Russian studies also saw shifts in IL-6 and T-helper cell balance (Uchakina 2008), which suggests a neuroimmune mechanism alongside the direct anxiolytic effect.
Sources- Inozemtseva et al. (2008)
- Uchakina et al. (2008)
Updated Sep 2026
Day 7–14Community
Memory and focus sharpening
Commonly reported by some: crisper memory recall and easier focus without the jittery edge (the memory effect itself comes from rodent studies). If you're stacking with Semax, users say this is where the two start to complement each other.
The science
BDNF supports synaptic plasticity and long-term potentiation, the biological basis of memory formation; no study has measured cumulative BDNF or plasticity changes with Selank. Human trials describe only mild nootropic effects.
Sources- Inozemtseva et al. (2008)
Updated Sep 2026
Day 14–28Clinical
Where the Russian courses stop
Commonly reported by now: a meaningfully lower anxiety baseline. Russian clinical studies ran about two weeks, and in one the calm lasted about a week after stopping. Selank is anxiolytic by nature, not a driver of long-term structural change, so continuing, pausing and cycling are all common from here.
The science
In 14-day Russian trials (about 60–70 patients each), Selank calmed anxiety about as well as benzodiazepine comparators, and the effect lasted about a week after stopping (Zozulia 2008; Medvedev 2014). The immune findings (IL-6, T-helper cell balance) are small and mixed in direction.
Sources- Zozulia et al. (2008)
- Medvedev et al. (2014)
Updated Sep 2026
With SemaxCommunity
The classic nootropic pair
Selank for calm and Semax for drive — different mechanisms, complementary effects. Selank lowers your anxiety floor while Semax raises your cognitive ceiling. Commonly reported: many users who try them separately end up running both.
The science
Selank acts on GABA/serotonin systems (anxiolytic), while Semax raises BDNF/NGF and serotonin turnover in rodents (nootropic). Both also inhibit enkephalin-degrading enzymes (Kost 2001). The combination aims at both anxiety-limited and motivation-limited cognition.
Sources- Kost et al. (2001)
- Dolotov et al. (2006)
Updated Sep 2026
Any dayClinical
What Selank is built on
Selank is an approved medication in Russia (since 2009), prescribed for generalized anxiety and neurasthenia. The clinical record is a few small Russian trials, mostly run by the developers — not Western RCT quality, but more human evidence than most peptides.
The science
Derived from tuftsin, a tetrapeptide the spleen naturally produces from immunoglobulin G. The synthetic analogue adds stabilizing amino acids for improved bioavailability. Approved by Russia's Ministry of Health as an anxiolytic. The main trials: Zozulia 2008 (62 patients, similar effect to medazepam), Medvedev 2014 (60, vs phenazepam) and Medvedev 2015 (70, as an add-on that cut phenazepam side effects).
Sources- Zozulia et al. (2008)
- Medvedev et al. (2014)
Updated Sep 2026
Day 1 is the day you start it.
Approved medication in Russia. Published research on anxiolytic effects and BDNF expression.
Moderate evidence
Mixing and a typical run.
Example numbers
Reconstitution example
Reconstitute a 5 mg vial of Selank with 2 mL of bacteriostatic water and a 375 mcg dose is 15 units on a U-100 syringe, about 13 doses per vial.
- Vial
- 5 mg
- Water
- 2 mL
- Amount
- 375 mcg
Draw to15 units
0.3 mL insulin syringe · 30 units
Run notes
- Cycle
- 2–4 week cycles typical. Can repeat with breaks. Tolerance generally low.Community practice — opinions vary. Not a clinical recommendation.
- Timing
- Nasal spray — 2x daily or as needed. Can be used situationally for anxiety.
- Routes
- Nasal spray, SubQ injection
- Stacks
- Semax, Pinealon
Safety.
Common side effects
- Mild nasal irritation
- Fatigue
- Slight dizziness
Compared with.
Questions people ask.
What is Selank?
A synthetic peptide based on tuftsin, an immune molecule your spleen naturally produces. In small Russian trials it eased anxiety about as well as benzodiazepine comparators, and no dependence has been reported, though it hasn't been formally studied. In rats it modulated GABA receptors and raised BDNF (a brain growth factor).
How is Selank dosed in research?
The research range for Selank is 250–500 mcg, daily. Studied in research — not a recommendation.
How long does Selank last?
The half-life of Selank is ~10 min in blood; nasal effect longer.
What do people report on Selank?
Commonly reported on Selank: calmer and less socially tense without feeling sedated, subtle effects for some, and mild tiredness at higher doses. Approved as an anxiety medication in Russia.
Is Selank safe?
The research basis for Selank is moderate: animal studies + some human data. Common side effects in the library: mild nasal irritation, fatigue and slight dizziness.
What does Selank stack with?
Common stacks for Selank: Semax and Pinealon. Curated stacks with Selank: Limitless.
Research.
Reference.
- Cadence
Daily
- Half-life
~10 min in blood
~10 min in blood; nasal effect longer
- Research basis
●●
●ModerateAnimal studies + some human data
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