Semax — dosage, half-life & reference guide

Cognitive peptide · also known as ACTH 4-7 Pro8Gly9Pro10, N-acetyl Semax

A nasal spray nootropic derived from ACTH but modified to remove hormonal effects — pure cognitive enhancement. Semax increases BDNF and nerve growth factor, sharpens focus within minutes, and improves mood and motivation. Approved in Russia for stroke recovery and cognitive decline. Often paired with Selank — Semax for drive, Selank for calm.

Commonly-researched dose ranges

Semax is commonly researched at 200–900 mcg, daily, by Nasal spray. These are reference ranges from the literature and community use, not a prescription.

Half-life

Estimated half-life: Very short (~minutes); CNS effects persist longer. See how it accumulates in the half-life calculator.

Safety & interactions

Commonly reported effects: nasal irritation, headache, anxiety, increased energy (can disrupt sleep). Discuss with your clinician.

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