Dihexa — dosage, half-life & reference guide

Cognitive peptide · also known as PNB-0408, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide

An extremely potent nootropic that promotes the formation of new synaptic connections between neurons. Dihexa works through the HGF/MET signaling pathway and is reported to be orders of magnitude more potent than BDNF at driving synaptogenesis. Effects persist for weeks after the last dose due to its long residual action. Very experimental — approach with caution.

Commonly-researched dose ranges

Dihexa is commonly researched at 10–30 mg, daily (cycle 4–8 weeks), by Oral, Topical (DMSO carrier). These are reference ranges from the literature and community use, not a prescription.

Half-life

Estimated half-life: Very long (weeks) — accumulates. See how it accumulates in the half-life calculator.

Safety & interactions

Commonly reported effects: overstimulation, insomnia, anxiety, vivid dreams, potential oncogenic risk (research stage). Discuss with your clinician.

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