P21 — dosage, half-life & reference guide

Cognitive peptide · also known as CNTF analog, P-21 peptide

A peptide analog of CNTF (a nerve growth factor) that promotes neurogenesis and synaptic plasticity. P21 is more stable than the parent protein and can cross the blood-brain barrier via nasal delivery. It may increase BDNF levels, supporting new neural connections and cognitive enhancement. Very limited human data.

Commonly-researched dose ranges

P21 is commonly researched at 100–300 mcg, daily, by Intranasal. These are reference ranges from the literature and community use, not a prescription.

Half-life

Estimated half-life: Unknown. See how it accumulates in the half-life calculator.

Safety & interactions

Commonly reported effects: limited human data, generally well tolerated, mild headache. Discuss with your clinician.

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