PT-141 — dosage, half-life & reference guide

Sexual health peptide · also known as Bremelanotide, PT141, Vyleesi

The only FDA-approved drug that increases sexual desire through the central nervous system rather than blood flow. PT-141 activates melanocortin receptors in the hypothalamus to boost arousal and libido in both men and women. It's a per-dose compound — you take it 1-2 hours before desired effect. Nausea is common, and frequent use can cause skin darkening.

Commonly-researched dose ranges

PT-141 is commonly researched at 0.5–2 mg, as needed, 1–2 hours before, by SubQ injection. These are reference ranges from the literature and community use, not a prescription.

Half-life

Estimated half-life: ~17 hours. See how it accumulates in the half-life calculator.

Safety & interactions

Commonly reported effects: nausea (most common), flushing, blood pressure elevation, spontaneous erections, hyperpigmentation with frequent use. Discuss with your clinician.

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