PT-141 dose guide

PT-141 dosage

An FDA-approved, as-needed treatment for low sexual desire in premenopausal women that acts through brain melanocortin receptors rather than blood flow (flibanserin/Addyi is the other, daily option). Small early studies in men showed erection effects. It's a per-dose compound, taken 1-2 hours before the desired effect. Commonly reported: a noticeable rise in desire and arousal an hour or so after dosing (men often describe firmer or spontaneous erections), nausea that is often worst with the first dose, facial flushing, and headache on dosing days. Frequent use can cause skin darkening.

Dose range

0.5–2 mg (research range). Trials and labels start at 1.25 mg and step up. Studied in research — not a recommendation. FDA-approved as Vyleesi: 1.75 mg SubQ as needed, at least 45 minutes before sex (at most once a day, 8 times a month), for premenopausal women with acquired, generalized low sexual desire (HSDD).

How often

As needed: As needed, 1–2 hours before

A typical run

As needed. As-needed use. Daily use leads to hyperpigmentation — limit frequency.

How it’s taken

Vial: SubQ injection

Evidence

Established: Clinical trials or FDA-approved use exists

Half-life

~2.7 hours (FDA label; range 1.9–4.0 hours)

PT-141 on your syringe

With a 10 mg vial and 2 mL of water (5 mg in every mL), on a 0.5 mL (50-unit) U-100 insulin syringe: the low end, 0.5 mg, is 10 units; the start, 1.25 mg, is 25 units; and the high end, 2 mg, is 40 units. 20 doses in the vial at the low end. All U-100: 100 units to the mL. A U-40 syringe reads differently.

PT-141 in the peptide libraryThe Dose Guide: every peptide

More sexual health peptides

• Gonadorelin 100 mcg
• Kisspeptin-10 50–500 mcg
• Enclomiphene 12.5–25 mg
• Melanotan II 250–500 mcg
• Melanotan I 250–1000 mcg

A community reference, not medical advice. Each range is what has been studied or is commonly run, never a dose for you.