Melanotan II — dosage, half-life & reference guide

Sexual health peptide · also known as MT-2, MT2, Melanotan 2

A broad-spectrum melanocortin agonist originally developed for sunless tanning. MT-2 stimulates melanocytes to produce melanin (requiring some UV exposure to activate), increases libido through central nervous system pathways, and suppresses appetite. PT-141 was actually derived from MT-2 by isolating its sexual arousal effects. Monitor moles carefully — it darkens all pigmented skin.

Commonly-researched dose ranges

Melanotan II is commonly researched at 250–500 mcg, loading: 250mcg daily for 1-2 weeks. maintenance: 250-500mcg 2-3x/week or as needed., by SubQ injection. These are reference ranges from the literature and community use, not a prescription.

Half-life

Estimated half-life: ~30-60 min (active metabolites last longer). See how it accumulates in the half-life calculator.

Safety & interactions

Commonly reported effects: nausea, facial flushing, spontaneous erections, fatigue, darkening of moles/freckles, yawning. Discuss with your clinician.

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