Klotho — dosage, half-life & reference guide

Longevity peptide · also known as α-Klotho, Alpha Klotho, Klotho protein

An aging-suppressor protein that declines significantly as you get older. Klotho enhances kidney function, reduces oxidative stress, improves insulin sensitivity, and has shown remarkable cognitive function improvements in preclinical studies. Higher natural Klotho levels are consistently associated with longer lifespans across multiple species.

Commonly-researched dose ranges

Klotho is commonly researched at 0.01–0.1 mg, weekly, by SubQ injection. These are reference ranges from the literature and community use, not a prescription.

Half-life

Estimated half-life: Unknown in research context. See how it accumulates in the half-life calculator.

Safety & interactions

Commonly reported effects: limited human data — research stage compound, injection site reaction. Discuss with your clinician.

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