Hexarelin Dosage, half-life & reference guide

Week by week.

What to expect in the first 8 weeks

1. Day 1–7Community

   A strong GH pulse from week one

   Commonly reported: Hexarelin hits as hard as any secretagogue, with a strong recovery signal, flushing or a head rush after injecting, and a distinct "something changed" feel in the first week. Don't expect deeper sleep: in the one sleep-lab study it reduced deep sleep. Keep the dose conservative; bigger isn't better with this one.

   The science

   Hexarelin is among the most potent GHRPs for peak GH release, similar to GHRP-2 in men (Arvat 1997). Nightly doses reduced deep (stage 4) sleep in young men (Frieboes 2004). It also binds heart receptors, including CD36; it protected rat hearts in ischemia models independently of GH (Locatelli 1999) and acutely raised heart pumping in small human studies (Broglio 2002).

   Sources

   • Arvat et al. (1997)
   • Frieboes et al. (2004)
   • Broglio et al. (2002)
   • Locatelli et al. (1999)

   Updated Sep 2026

2. Day 7–28Clinical

   Productive window — but watch the clock

   Commonly reported: the peak productive phase, with recovery and body-composition signals firing. This is also when the GH response starts to fade — if effects feel softer by the end of this window, it's not your imagination.

   The science

   With twice-daily dosing in older adults, the GH response dropped about a third within 1–4 weeks, then plateaued, and recovered after 4 weeks off (Rahim 1998). Cortisol and prolactin rise after a dose, though 16 weeks of use didn't raise either (Rahim 1999). Some users split lower doses to slow the fade.

   Sources

   • Rahim et al. (1998)
   • Rahim et al. (1999)

   Updated Sep 2026

3. Day 28–42Clinical

   Time to cycle off

   You're at the end of the usual community cycle. In the one long study, the GH response had dropped by about a third by this point, even for people who didn't feel it. Community practice is a 4+ week break here; in that study, the response recovered after 4 weeks off.

   The science

   In older adults dosing twice daily, the GH response fell about 31% by week 1 and 45% by week 16, then recovered after 4 weeks off (Rahim 1998). In aged rats, by contrast, 30–60 days of hexarelin kept the GH response intact (Cattaneo 1997). Unlike Ipamorelin, Hexarelin is usually run in short cycles.

   Sources

   • Rahim et al. (1998)
   • Cattaneo et al. (1997)

   Updated Sep 2026

4. Any dayClinical

   What Hexarelin is built on

   Hexarelin has small human studies on GH release and some of the most interesting heart findings of any GH peptide: in rats it protected heart muscle through a pathway independent of GH, and single doses raised heart pumping in small human studies. The short-cycle habit comes from its fading GH response.

   The science

   Phase 1/2 data on GH release is published (Imbimbo 1994). Separately, Hexarelin binds heart receptors (GHS-R1a and CD36) and reduced ischemia-reperfusion injury in rats (Locatelli 1999); in humans, single IV doses raised heart pumping (Bisi 1999; Broglio 2002), though not in dilated cardiomyopathy (Imazio 2002). It never advanced to late-phase development; no reason was published, and chronic use had minimal effect on IGF-1 and body composition (Rahim 1998).

   Sources

   • Broglio et al. (2002)
   • Bisi et al. (1999)
   • Rahim et al. (1998)

   Updated Sep 2026

Swipe for more ›

Mixing and a typical run.

Safety.

Goes with.

• CJC-1295 no DAC
• BPC-157

Questions people ask.

Research.

Reference.

Cadence

2–3× daily

2–3x daily

Half-life

~55–70 min

~55–70 min (community estimate; not measured in people: in rats it lasted ~76 minutes, in dogs ~2 hours)

Research basis

●●● Moderate

Animal studies + some human data