SS-31 dose guide

SS-31 dosage

A mitochondria-targeting peptide that binds directly to cardiolipin — a key lipid in the inner mitochondrial membrane where your cells generate energy. It stabilizes this membrane and cuts oxidative stress at its source, as shown in cell and animal studies. FDA-approved in 2025 as elamipretide (Forzinity) for the rare disease Barth syndrome; trials in mitochondrial myopathy and heart failure missed their main goals. Commonly reported: injection-site redness, itching or welts (very common), and for some, steadier stamina with less post-exertion crash over weeks.

Dose range

2–4 mg (research range). Studied in research — not a recommendation. FDA-approved as Forzinity (elamipretide): 40 mg SubQ once daily, to improve muscle strength in adults and children with Barth syndrome who weigh at least 30 kg (accelerated approval).

How often

Daily

A typical run

Daily or EOD use. Cycles of 4–8 weeks common; some run continuously. The Forzinity label doses it once daily with no break.

How it’s taken

Vial: SubQ injection

Evidence

Emerging: Primarily preclinical / limited human data

Half-life

Short (hours)

SS-31 on your syringe

With a 10 mg vial and 2 mL of water (5 mg in every mL), on a 1 mL (100-unit) U-100 insulin syringe: the low end, 2 mg, is 40 units; and the high end, 4 mg, is 80 units. 5 doses in the vial at the low end. All U-100: 100 units to the mL. A U-40 syringe reads differently.

SS-31 in the peptide libraryThe Dose Guide: every peptide

More longevity peptides

• MOTS-c 5–10 mg
• NAD+ 50–100 mg
• Glutathione 100–600 mg
• Epitalon 5–10 mg
• Humanin 2–4 mg
• FOXO4-DRI 1–2 mg
• Pinealon 100–200 mcg
• Vesugen No reference dose
• Klotho 0.01–0.1 mg
• NMN 250–1000 mg
• SNAP-8 3–10%
• DSIP 200–400 mcg

A community reference, not medical advice. Each range is what has been studied or is commonly run, never a dose for you.