NAD+ dose guide

NAD+ dosage

NAD+ is a coenzyme every cell needs to turn food into usable energy, and the molecule your sirtuin "longevity" enzymes and DNA-repair machinery run on. Levels fall in some tissues with age, and supplementing aims to top the pool back up. Commonly reported: a lift in energy and mental clarity within days, and flushing or nausea when it goes in too fast. Most human evidence is for the oral precursors (NMN and NR); injected NAD+ is popular but has little controlled data.

Dose range

50–100 mg (research range). Studied in research — not a recommendation.

How often

Daily: Daily or EOD

A typical run

2–6 week blocks. Often run in 2–6 week blocks, 2–3× per year, or low-dose continuous. Inject slowly — the hallmark NAD+ flush/nausea is dose-RATE dependent, not dose-amount dependent. No standardized injectable protocol exists; ranges are extrapolated from IV practice + community use. Often stacked with glutathione.

How it’s taken

Vial: SubQ injection, IV infusion, Intranasal

Evidence

Emerging: Primarily preclinical / limited human data

Half-life

Minutes (rapidly metabolized)

NAD+ on your syringe

With a 10 mg vial and 2 mL of water (5 mg in every mL), on a 1 mL (100-unit) U-100 insulin syringe: the low end, 50 mg, needs more than this vial holds; and the high end, 100 mg, needs more than this vial holds. All U-100: 100 units to the mL. A U-40 syringe reads differently.

NAD+ in the peptide libraryThe Dose Guide: every peptide

More longevity peptides

• MOTS-c 5–10 mg
• Glutathione 100–600 mg
• Epitalon 5–10 mg
• Humanin 2–4 mg
• FOXO4-DRI 1–2 mg
• SS-31 2–4 mg
• Pinealon 100–200 mcg
• Vesugen No reference dose
• Klotho 0.01–0.1 mg
• NMN 250–1000 mg
• SNAP-8 3–10%
• DSIP 200–400 mcg

A community reference, not medical advice. Each range is what has been studied or is commonly run, never a dose for you.