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Semaglutide (oral) — dosage, half-life & reference guide

Metabolic & GLP-1 peptide · also known as Rybelsus, Wegovy pill, Ozempic pill, Oral semaglutide

Semaglutide as a daily tablet instead of a weekly shot. It's sold as Rybelsus (3, 7 and 14 mg) and Ozempic tablets (1.5, 4 and 9 mg) for type 2 diabetes, and as Wegovy tablets (up to 25 mg) for weight management. Each line has its own dose steps, so log the strength on your pack.

Commonly-researched dose ranges

Semaglutide (oral) is commonly researched at 1.5–25 mg, daily, by Oral tablet. These are reference ranges from the literature and community use, not a prescription.

Half-life

Estimated half-life: ~1 week. See how it accumulates in the half-life calculator.

Safety & interactions

Both tablet labels carry the GLP-1 class boxed warning for thyroid C-cell tumors seen in rodents, plus the weekly shot's pancreatitis, gallbladder and low-blood-sugar (with insulin or sulfonylureas) warnings. These are label findings; review them with your clinician.

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