The short answer
Fragment 176-191 is a stabilized fragment of growth hormone (amino acids 176-191), and it is usually the same peptide as AOD-9604, which is hGH 177-191 with an added tyrosine. In rodents both boosted the breakdown of stored fat without affecting blood sugar or IGF-1. In people, as AOD-9604, one 12-week trial found modest weight loss and a larger 24-week trial didn’t.
Side by side
| Compared | AOD-9604 | Fragment 176-191 |
|---|---|---|
| Category | Healing & recovery | Growth hormone |
| Also known as | Anti-Obesity Drug 9604, HGH Fragment 177-191 | HGH Fragment 176-191, HGH Frag, AOD Fragment |
| What it is | A modified fragment of human growth hormone that targets fat metabolism. | A stabilized fragment of the growth hormone molecule (amino acids 176-191), usually sold as the same peptide as AOD-9604. |
| How it works | Modified fragment of human growth hormone (HGH) that stimulates lipolysis and inhibits lipogenesis (shown in rat and mouse fat tissue) without affecting blood sugar or IGF-1. Cartilage repair was seen in one rabbit study. | Stabilized fragment of HGH amino acids 176-191, usually the same peptide as AOD-9604 (hGH 177-191 with an added tyrosine). Boosts fat breakdown (rodent studies) without affecting blood glucose or IGF-1 levels; in obese mice it raised beta-3 receptor levels rather than binding them directly. |
| Commonly reported | Little noticeable effect for many users, slow fat loss for others when paired with diet and training, and mild injection-site redness. | Subtle at best, with many users noticing little and some describing slow fat loss with fasted morning dosing and a diet, plus mild injection-site redness. Human trials (as AOD-9604) found modest weight loss at best. |
| Studied range | Research range: 250–300 mcg. Studied in research — not a recommendation. | Research range: 250–500 mcg. Studied in research — not a recommendation. |
| How often | Daily, fasted | Daily, split into 2 doses, fasted |
| Half-life | ~30 min | ~30 min |
| Route | SubQ injection | SubQ injection |
| Typical run | 12–16 weeks common. Diminishing returns reported beyond 16 weeks; cycling recommended. | 12–16 weeks. Often cycled alongside CJC/Ipa stack. Plateau reported; cycling advised. |
| Evidence | Moderate: animal studies + some human data | Moderate: animal studies + some human data |
| Common side effects | Injection site reaction, mild headache, nausea | Injection site reactions, generally well tolerated, mild flushing |
- Category
- AOD-9604Healing & recovery
- Fragment 176-191Growth hormone
- Also known as
- AOD-9604Anti-Obesity Drug 9604, HGH Fragment 177-191
- Fragment 176-191HGH Fragment 176-191, HGH Frag, AOD Fragment
- What it is
- AOD-9604A modified fragment of human growth hormone that targets fat metabolism.
- Fragment 176-191A stabilized fragment of the growth hormone molecule (amino acids 176-191), usually sold as the same peptide as AOD-9604.
- How it works
- AOD-9604Modified fragment of human growth hormone (HGH) that stimulates lipolysis and inhibits lipogenesis (shown in rat and mouse fat tissue) without affecting blood sugar or IGF-1. Cartilage repair was seen in one rabbit study.
- Fragment 176-191Stabilized fragment of HGH amino acids 176-191, usually the same peptide as AOD-9604 (hGH 177-191 with an added tyrosine). Boosts fat breakdown (rodent studies) without affecting blood glucose or IGF-1 levels; in obese mice it raised beta-3 receptor levels rather than binding them directly.
- Commonly reported
- AOD-9604Little noticeable effect for many users, slow fat loss for others when paired with diet and training, and mild injection-site redness.
- Fragment 176-191Subtle at best, with many users noticing little and some describing slow fat loss with fasted morning dosing and a diet, plus mild injection-site redness. Human trials (as AOD-9604) found modest weight loss at best.
- Studied range
- AOD-9604Research range: 250–300 mcg. Studied in research — not a recommendation.
- Fragment 176-191Research range: 250–500 mcg. Studied in research — not a recommendation.
- How often
- AOD-9604Daily, fasted
- Fragment 176-191Daily, split into 2 doses, fasted
- Half-life
- AOD-9604~30 min
- Fragment 176-191~30 min
- Route
- AOD-9604SubQ injection
- Fragment 176-191SubQ injection
- Typical run
- AOD-960412–16 weeks common. Diminishing returns reported beyond 16 weeks; cycling recommended.
- Fragment 176-19112–16 weeks. Often cycled alongside CJC/Ipa stack. Plateau reported; cycling advised.
- Evidence
- AOD-9604Moderate: animal studies + some human data
- Fragment 176-191Moderate: animal studies + some human data
- Common side effects
- AOD-9604Injection site reaction, mild headache, nausea
- Fragment 176-191Injection site reactions, generally well tolerated, mild flushing
Typical run: Community practice — opinions vary. Not a clinical recommendation.
Week by week
Each entry’s cards by day window, as the compound pages show them. Day 1 is the day you start it.
AOD-9604
- Day 1–7 A quiet first week
- Day 7–21 Subtle changes, for some users
- Day 21–42 Body composition is shifting
- Day 42–84 Judge it at week 12
Fragment 176-191
- Day 1–14 No GH effects to feel
- Day 14–56 A slow drift, for some users
- Day 56–112 Plateau is a real thing here
Questions people ask
How long do AOD-9604 and Fragment 176-191 last?
The half-life of AOD-9604 is ~30 min. The half-life of Fragment 176-191 is ~30 min.
How often are AOD-9604 and Fragment 176-191 taken?
AOD-9604: daily, fasted. Route: SubQ injection. Fragment 176-191: daily, split into 2 doses, fasted. Route: SubQ injection.
How are AOD-9604 and Fragment 176-191 dosed in research?
The research range for AOD-9604 is 250–300 mcg. The research range for Fragment 176-191 is 250–500 mcg. Studied in research — not a recommendation.
What are the common side effects of AOD-9604 and Fragment 176-191?
For AOD-9604, the library lists: injection site reaction, mild headache, nausea. For Fragment 176-191: injection site reactions, generally well tolerated, mild flushing.
Each one in full
PepVault for iPhone
Track either one in PepVault
Log every dose of AOD-9604 or Fragment 176-191, with reminders on your schedule. 7 days free on the yearly plan for new subscribers.
