NSI-189 dose guide

A peptide dosage chart, one peptide at a time: its dose range, how often it’s taken, a typical run and the units on your syringe. All 69 peptides in the PepVault library.

A community reference, not medical advice. Each range is what has been studied or is commonly run, never a dose for you.

NSI-189 dosage

An investigational drug (a small molecule, not a peptide) that stimulated the growth of new neurons in the hippocampus of mice — the brain region critical for memory and mood. Its phase 2 depression trial missed its main goal, though some thinking and mood scores improved at the lower dose, and a later phase 2b failed too. Commonly reported: a slow, gradual lift in mood and mental clarity over weeks, headaches and sometimes irritability or anxiety early on, and for many, no noticeable effect.

Dose range
40–80 mg (research range). Studied in research — not a recommendation.
How often
Daily: Daily, split into 2 doses
A typical run
8 weeks on, 4 off commonly cited. In a small trial, some gains held for weeks after a 4-week course.
How it’s taken
Taken by mouth: Oral
Evidence
Emerging: Primarily preclinical / limited human data
Half-life
About 17–20 hours (human data)

NSI-189 on your syringe

Taken by mouth, so there’s nothing to draw.

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A community reference, not medical advice. Each range is what has been studied or is commonly run, never a dose for you.