# Semaglutide (oral) — dosage, half-life & reference guide Source: https://pepvault.app/peptides/semaglutide-oral Last updated: 2026-09-26 [Library](https://pepvault.app/peptides) [Metabolic & GLP-1](https://pepvault.app/peptides#metabolic) reviewed September 2026 # Semaglutide (oral) Dosage, half-life & reference guide Also known as Rybelsus · Wegovy pill · Ozempic pill · Oral semaglutide Semaglutide as a daily tablet instead of a weekly shot, FDA-approved as Rybelsus (3, 7 and 14 mg) and Ozempic tablets (1.5, 4 and 9 mg) for type 2 diabetes and as Wegovy tablets (up to 25 mg) for weight management. - **FDA label:** 1.5–25 mg starting dose 1.5 mg - **How often:** Daily - **Half-life:** ~1 week - **Evidence:** Established - **Route:** Oral tablet [Semaglutide (oral) dose guide](https://pepvault.app/lab/dosage/semaglutide-oral) ## How it works. The same GLP-1 receptor agonist as the weekly injection, made into a daily tablet with an absorption enhancer (SNAC). The Rybelsus and Ozempic tablet label puts absorption at about 0.4–2% of each tablet, which is why tablet doses run in whole milligrams while the weekly shot is a fraction of one. **Commonly reported:** The strict morning routine is the hardest part, and nausea after each dose step feels much like the injection. Each line has its own dose steps, so log the strength on your pack. ## Where Semaglutide (oral) works. - ### Appetite & metabolism **In people.** Used for type 2 diabetes, and as Wegovy tablets for weight management. An area lights for what a peptide is used for and what people report, with the evidence beside it. It isn’t a promise that it works there. ## A typical run. ### Run notes - **Timing:** Per the labels: one tablet on an empty stomach on waking, with up to 4 oz of plain water, then at least 30 minutes before food, drinks or other oral medicines. - **Route:** Oral tablet ## Safety. ### Common side effects - Nausea - Abdominal pain - Diarrhea - Decreased appetite - Vomiting - Constipation #### Interactions The Wegovy label advises against taking its tablets with other semaglutide products or any other GLP-1 drug. ### Safety notes Both tablet labels carry the GLP-1 class boxed warning for thyroid C-cell tumors seen in rodents, plus the weekly shot's pancreatitis, gallbladder and low-blood-sugar (with insulin or sulfonylureas) warnings. These are label findings; review them with your clinician. ## Questions people ask. ### What is Semaglutide (oral)? Semaglutide as a daily tablet instead of a weekly shot, FDA-approved as Rybelsus (3, 7 and 14 mg) and Ozempic tablets (1.5, 4 and 9 mg) for type 2 diabetes and as Wegovy tablets (up to 25 mg) for weight management. ### How is Semaglutide (oral) dosed in research? The FDA label range for Semaglutide (oral) is 1.5–25 mg, daily, with a 1.5 mg starting dose. ### How long does Semaglutide (oral) last? The half-life of Semaglutide (oral) is ~1 week. ### What do people report on Semaglutide (oral)? Commonly reported on Semaglutide (oral): the strict morning routine is the hardest part, and nausea after each dose step feels much like the injection. Each line has its own dose steps, so log the strength on your pack. ### Is Semaglutide (oral) safe? The research basis for Semaglutide (oral) is established: clinical trials or FDA-approved use exists. Common side effects in the library: nausea, abdominal pain, diarrhea, decreased appetite, vomiting and constipation. ## Research. The literature ### Search the latest research [PubMed](https://pubmed.ncbi.nlm.nih.gov/?term=Semaglutide%20%28oral%29) [Google Scholar](https://scholar.google.com/scholar?q=Semaglutide%20%28oral%29) ## Reference. - **Cadence:** Daily - **Half-life:** ~1 week - **Research basis:** Established Clinical trials or FDA-approved use exists ## More metabolic & glp-1 peptides - [Tirzepatide 2.5–15 mg](https://pepvault.app/peptides/tirzepatide) - [Retatrutide 1–12 mg](https://pepvault.app/peptides/retatrutide) - [Liraglutide 0.6–3 mg](https://pepvault.app/peptides/liraglutide) - [Dulaglutide 0.75–4.5 mg](https://pepvault.app/peptides/dulaglutide) - [Orforglipron 0.8–17.2 mg](https://pepvault.app/peptides/orforglipron) - [Survodutide 0.3–6 mg](https://pepvault.app/peptides/survodutide) ## Free tools - [Semaglutide (oral) dose guide](https://pepvault.app/lab/dosage/semaglutide-oral) - [Peptide Sky (3D)](https://pepvault.app/lab/sky) - [Peptide tier list](https://pepvault.app/lab/tiers) - [Reconstitution calculator](https://pepvault.app/tools/reconstitution-calculator) - [Half-life & active level](https://pepvault.app/tools/peptide-half-life-calculator) - [GLP-1 titration planner](https://pepvault.app/tools/glp1-titration-calculator) Track your progress ## Watch it *work.* Weight, waist and photos in one arc. [Download on the App Store](https://apps.apple.com/app/apple-store/id6779318649?ppid=616838ec-3248-400f-bd58-4b93f85f1a20&pt=129020030&ct=peptides-progress-band&mt=8) **34.8 lbs** down since June Model. Individual results vary. PepVault for iPhone ## Track Semaglutide (oral) in PepVault Log every dose, with reminders on your schedule. 7 days free on the yearly plan for new subscribers. [Download on the App Store](https://apps.apple.com/app/apple-store/id6779318649?ppid=616838ec-3248-400f-bd58-4b93f85f1a20&pt=129020030&ct=peptides-cta&mt=8) [Explore the live demo](https://pepvault.app/login) Reviewed September 2026 [How we check the library](https://pepvault.app/about#library) PepVault is a research and tracking resource, not medical advice. Ranges are what studies used, never a dose for you. Brand names are trademarks of their owners; PepVault is independent of them. PepVault is a private research and tracking tool, not medical advice. The information here is reference material from published literature and community use — always verify it and discuss any protocol with a qualified clinician before changing it. Ozempic, Wegovy, Rybelsus, Mounjaro, Zepbound, Saxenda, Victoza and Trulicity are trademarks of their respective owners; PepVault is independent and not affiliated with or endorsed by any manufacturer. © 2026 PepVault