# Kisspeptin-10 — dosage, half-life & reference guide

Source: https://pepvault.app/peptides/kisspeptin-10

Last updated: 2026-09-26

[Library](https://pepvault.app/peptides) [Sexual health](https://pepvault.app/peptides#sexual-health) reviewed September 2026

# Kisspeptin-10 Dosage, half-life & reference guide

Also known as KP-10 · Kisspeptin · Metastin fragment

A hypothalamic neuropeptide that sits upstream of GnRH in your hormonal cascade — it's the signal that tells your brain to start producing reproductive hormones. In men, kisspeptin-10 raises LH within 30–60 minutes and testosterone over the following hours; it relies on your own GnRH neurons still working. Research-stage, with fertility trials recruiting.

- **Studied range:** 50–500 mcg
- **How often:** 2–3× weekly
- **Half-life:** ~4 min
- **Evidence:** Emerging
- **Route:** SubQ injection

Studied in research — not a recommendation.

[Kisspeptin-10 dose guide](https://pepvault.app/lab/dosage/kisspeptin-10)

## How it works.

Hypothalamic neuropeptide that stimulates GnRH release, driving LH and FSH production. Key regulator of the HPG (hypothalamic-pituitary-gonadal) axis. Phase 2 trials in hypogonadism and hypothalamic amenorrhea are recruiting. In men, LH rises within 30–60 minutes of a dose, with testosterone following over hours.

**Commonly reported:** A libido or mood lift within hours of a dose for some, while many find the effects subtle or short-lived.

## Where Kisspeptin-10 works.

- ### Sex & hormones

  **In people.** In men, LH rises within 30–60 minutes of a dose, with testosterone following over hours.

An area lights for what a peptide is used for and what people report, with the evidence beside it. It isn’t a promise that it works there.

## Week by week.

What to expect in the first 8 weeks

1. Day 1–7 Clinical

   ### Fast LH and testosterone surge

   Kisspeptin-10 works upstream of GnRH — the "wake-up call" of the HPG axis. In studies in men, LH rose within 30–60 min of a dose, with testosterone following over a few hours. Commonly reported: a mood, libido or energy lift within the first few doses for some; many find it subtle.

   The science

   Kisspeptin-10 activates KISS1R (GPR54) on hypothalamic neurons, triggering GnRH release upstream of the pituitary. Dhillo et al. 2005 (kisspeptin-54) and George et al. 2011 (kisspeptin-10) showed LH rising within 30–60 minutes in men, with testosterone following. Phase 2 trials in hypogonadism and hypothalamic amenorrhea are recruiting.

   Sources

   - Dhillo et al. (2005)
   - George et al. (2011)

   Updated Sep 2026
2. Day 7–28 Clinical

   ### HPG axis coming online

   Community protocols settle into 2–3x/week dosing here; no human study has tested that schedule. Kisspeptin-10 works one step upstream of gonadorelin: it prompts your own GnRH neurons to fire, so it relies on that part of the system still working (gonadorelin skips it and acts on the pituitary directly).

   The science

   In healthy men, daily 8-hour infusions of kisspeptin-10 for 12 days kept LH and FSH raised, while continuous infusion for 5 days let them fall back (Yeung 2026). In men with low sexual desire, a single infusion of the longer kisspeptin-54 boosted sexual-brain activity and erection response to erotic videos (Mills 2023). The kisspeptin → GnRH → LH/FSH cascade is the physiological upstream route, making kisspeptin a candidate for HPG axis restoration protocols.

   Sources

   - Yeung et al. (2026)
   - Mills et al. (2023)

   Updated Sep 2026
3. Day 28–84 Clinical

   ### Assess labs, decide next step

   At 1–3 months, pull labs — total T, free T, LH, FSH. Kisspeptin-10 protocols are typically run in cycles until either the HPG axis restart is confirmed (post-cycle context) or ongoing use is decided (fertility context). Long-term chronic dosing data is limited.

   The science

   Human studies of kisspeptin-10 have been acute or short (up to 12 days); the longest repeated-dosing data are for kisspeptin-54 (twice weekly for 8 weeks in women with hypothalamic amenorrhea, with partial desensitization). Long-term safety and tachyphylaxis with chronic use aren't characterized. Cycle-and-reassess is the conservative approach.

   Sources

   - Yeung et al. (2026)
   - Jayasena et al. (2010)

   Updated Sep 2026
4. Any day Clinical

   ### What Kisspeptin-10 is built on

   Kisspeptin has genuine clinical trial evidence from the Dhillo group at Imperial College and others, mostly for the longer kisspeptin-54 form (IVF and low libido); kisspeptin-10's human data are shorter hormone-response studies, with fertility trials now recruiting. Not yet FDA-approved for any indication, but among the best-studied of the research-stage sexual health peptides.

   The science

   Active NIH clinical trials for hypogonadism and fertility indications. The kisspeptin system is itself a relatively recent discovery (KISS1/GPR54 identified as HPG axis regulator in 2003), which is why clinical use is still being characterized. Safety profile in completed trials has been clean; FDA lists kisspeptin-10 in compounding category 2.

   Sources

   - Dhillo et al. (2005)
   - George et al. (2011)
   - Mills et al. (2023)

   Updated Sep 2026

Day 1 is the day you start it.

## Mixing and a typical run.

Example numbers

### Reconstitution example

Reconstitute a 5 mg vial of Kisspeptin-10 with 2 mL of bacteriostatic water and a 275 mcg dose is 11 units on a U-100 syringe, about 18 doses per vial.

- **Vial:** 5 mg
- **Water:** 2 mL
- **Amount:** 275 mcg

Draw to **11 units**

0.3 mL insulin syringe · 30 units

[Mix it in the Reconstitution Lab](https://pepvault.app/lab) [Open the calculator](https://pepvault.app/tools/reconstitution-calculator)

### Run notes

- **Cycle:** Pulsatile 2–3x/week. Limited long-term community data. Used in defined cycles. Community practice — opinions vary. Not a clinical recommendation.
- **Timing:** Morning injection common. Expect LH/T surge within hours.
- **Route:** SubQ injection
- **Stacks:** Gonadorelin, PT-141

## Safety.

### Common side effects

- Limited human data
- LH/testosterone surge after dosing
- Potential mood effects
- Injection site reaction

## Goes with.

- [Gonadorelin](https://pepvault.app/peptides/gonadorelin)
- [PT-141](https://pepvault.app/peptides/pt-141)

## Questions people ask.

### What is Kisspeptin-10?

A hypothalamic neuropeptide that sits upstream of GnRH in your hormonal cascade — it's the signal that tells your brain to start producing reproductive hormones. In men, kisspeptin-10 raises LH within 30–60 minutes and testosterone over the following hours; it relies on your own GnRH neurons still working. Research-stage, with fertility trials recruiting.

### How is Kisspeptin-10 dosed in research?

The research range for Kisspeptin-10 is 50–500 mcg, pulsatile — 2–3x/week. Studied in research — not a recommendation.

### How long does Kisspeptin-10 last?

The half-life of Kisspeptin-10 is ~4 min (kisspeptin-54, a longer form, lasts ~28 min).

### What do people report on Kisspeptin-10?

Commonly reported on Kisspeptin-10: A libido or mood lift within hours of a dose for some, while many find the effects subtle or short-lived.

### Is Kisspeptin-10 safe?

The research basis for Kisspeptin-10 is emerging: primarily preclinical / limited human data. Common side effects in the library: limited human data, LH/testosterone surge after dosing, potential mood effects and injection site reaction.

### What does Kisspeptin-10 stack with?

Common stacks for Kisspeptin-10: Gonadorelin and PT-141.

## Research.

The literature

### Search the latest research

[PubMed](https://pubmed.ncbi.nlm.nih.gov/?term=Kisspeptin-10) [Google Scholar](https://scholar.google.com/scholar?q=Kisspeptin-10)

## Reference.

- **Cadence:** 2–3× weekly Pulsatile — 2–3x/week
- **Half-life:** ~4 min ~4 min (kisspeptin-54, a longer form, lasts ~28 min)
- **Research basis:** Emerging Primarily preclinical / limited human data

## More sexual health peptides

- [Enclomiphene 12.5–25 mg](https://pepvault.app/peptides/enclomiphene)
- [Melanotan II 250–500 mcg](https://pepvault.app/peptides/melanotan-ii)
- [Melanotan I 250–1000 mcg](https://pepvault.app/peptides/melanotan-i)

## Free tools

- [Kisspeptin-10 dose guide](https://pepvault.app/lab/dosage/kisspeptin-10)
- [Reconstitution Lab (3D)](https://pepvault.app/lab)
- [Injection guide (3D)](https://pepvault.app/lab/injection)
- [Peptide Sky (3D)](https://pepvault.app/lab/sky)
- [Peptide tier list](https://pepvault.app/lab/tiers)
- [Reconstitution calculator](https://pepvault.app/tools/reconstitution-calculator)
- [Half-life & active level](https://pepvault.app/tools/peptide-half-life-calculator)

PepVault for iPhone

## Track Kisspeptin-10 in PepVault

Log every dose and keep your vial and the doses left in it. 7 days free on the yearly plan for new subscribers.

[Download on the App Store](https://apps.apple.com/app/apple-store/id6779318649?pt=129020030&ct=peptides-cta&mt=8)

[Open the calculator](https://pepvault.app/tools/reconstitution-calculator) [How the vial count works](https://pepvault.app/peptide-vial-tracker-app) [Explore the live demo](https://pepvault.app/login)

Reviewed September 2026 [How we check the library](https://pepvault.app/about#library)

PepVault is a research and tracking resource, not medical advice. Ranges are what studies used, never a dose for you. Brand names are trademarks of their owners; PepVault is independent of them.

PepVault is a private research and tracking tool, not medical advice. The information here is reference material from published literature and community use — always verify it and discuss any protocol with a qualified clinician before changing it.

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