# Hexarelin — dosage, half-life & reference guide | PepVault Source: https://pepvault.app/peptides/hexarelin Last updated: 2026-09-26 [Library](https://pepvault.app/peptides) [Growth hormone](https://pepvault.app/peptides#growth-hormone) reviewed September 2026 # Hexarelin Dosage, half-life & reference guide Also known as Examorelin One of the most powerful GH secretagogues, with a catch: the response fades. Hexarelin gives some of the largest GH spikes, but with daily use the response drops partly over weeks and recovers after a break. - **Studied range:** 100–200 mcg - **How often:** 2–3× daily - **Half-life:** ~55–70 min - **Evidence:** Moderate - **Route:** SubQ injection Studied in research — not a recommendation. [Hexarelin dose guide](https://pepvault.app/lab/dosage/hexarelin) ## How it works. One of the most potent GHRPs (on par with GHRP-2 in humans). Strongly stimulates GH release, and in rat studies it protected heart muscle independently of GH. The GH response fades partly within weeks of ongoing use and recovers after a break — cycle carefully. **Commonly reported:** A strong effect at first, flushing or a head rush after injecting, and water retention with some hunger (less than GHRP-6). In rats it also protected the heart through a pathway independent of GH. ### Half-life & active level The half-life of Hexarelin is ~55–70 min (community estimate; not measured in people: in rats it lasted ~76 minutes, in dogs ~2 hours). Here's how a typical Hexarelin schedule plays out over 48 hours (one-compartment estimate). An estimate from the half-life above, not a measurement. See your own curve build live in [the half-life calculator](https://pepvault.app/tools/peptide-half-life-calculator). ## Where Hexarelin works. - ### Heart & blood vessels **In people.** In rats it protected heart muscle through a pathway independent of GH, and single doses raised heart pumping in small human studies. - ### Muscle **Reported by users.** Commonly reported: Hexarelin hits as hard as any secretagogue, with a strong recovery signal. An area lights for what a peptide is used for and what people report, with the evidence beside it. It isn’t a promise that it works there. ## Week by week. What to expect in the first 8 weeks 1. Day 1–7 Community ### A strong GH pulse from week one Commonly reported: Hexarelin hits as hard as any secretagogue, with a strong recovery signal, flushing or a head rush after injecting, and a distinct "something changed" feel in the first week. Don't expect deeper sleep: in the one sleep-lab study it reduced deep sleep. Keep the dose conservative; bigger isn't better with this one. The science Hexarelin is among the most potent GHRPs for peak GH release, similar to GHRP-2 in men (Arvat 1997). Nightly doses reduced deep (stage 4) sleep in young men (Frieboes 2004). It also binds heart receptors, including CD36; it protected rat hearts in ischemia models independently of GH (Locatelli 1999) and acutely raised heart pumping in small human studies (Broglio 2002). Sources - Arvat et al. (1997) - Frieboes et al. (2004) - Broglio et al. (2002) - Locatelli et al. (1999) Updated Sep 2026 2. Day 7–28 Clinical ### Productive window — but watch the clock Commonly reported: the peak productive phase, with recovery and body-composition signals firing. This is also when the GH response starts to fade — if effects feel softer by the end of this window, it's not your imagination. The science With twice-daily dosing in older adults, the GH response dropped about a third within 1–4 weeks, then plateaued, and recovered after 4 weeks off (Rahim 1998). Cortisol and prolactin rise after a dose, though 16 weeks of use didn't raise either (Rahim 1999). Some users split lower doses to slow the fade. Sources - Rahim et al. (1998) - Rahim et al. (1999) Updated Sep 2026 3. Day 28–42 Clinical ### Time to cycle off You're at the end of the usual community cycle. In the one long study, the GH response had dropped by about a third by this point, even for people who didn't feel it. Community practice is a 4+ week break here; in that study, the response recovered after 4 weeks off. The science In older adults dosing twice daily, the GH response fell about 31% by week 1 and 45% by week 16, then recovered after 4 weeks off (Rahim 1998). In aged rats, by contrast, 30–60 days of hexarelin kept the GH response intact (Cattaneo 1997). Unlike Ipamorelin, Hexarelin is usually run in short cycles. Sources - Rahim et al. (1998) - Cattaneo et al. (1997) Updated Sep 2026 4. Any day Clinical ### What Hexarelin is built on Hexarelin has small human studies on GH release and some of the most interesting heart findings of any GH peptide: in rats it protected heart muscle through a pathway independent of GH, and single doses raised heart pumping in small human studies. The short-cycle habit comes from its fading GH response. The science Phase 1/2 data on GH release is published (Imbimbo 1994). Separately, Hexarelin binds heart receptors (GHS-R1a and CD36) and reduced ischemia-reperfusion injury in rats (Locatelli 1999); in humans, single IV doses raised heart pumping (Bisi 1999; Broglio 2002), though not in dilated cardiomyopathy (Imazio 2002). It never advanced to late-phase development; no reason was published, and chronic use had minimal effect on IGF-1 and body composition (Rahim 1998). Sources - Broglio et al. (2002) - Bisi et al. (1999) - Rahim et al. (1998) Updated Sep 2026 Day 1 is the day you start it. ## Mixing and a typical run. Example numbers ### Reconstitution example Reconstitute a 5 mg vial of Hexarelin with 2 mL of bacteriostatic water and a 150 mcg dose is 6 units on a U-100 syringe, about 33 doses per vial. - **Vial:** 5 mg - **Water:** 2 mL - **Amount:** 150 mcg Draw to **6 units** 0.3 mL insulin syringe · 30 units [Mix it in the Reconstitution Lab](https://pepvault.app/lab) [Open the calculator](https://pepvault.app/tools/reconstitution-calculator) ### Run notes - **Cycle:** Community protocols keep cycles short (4–6 weeks) because the GH response fades partly with ongoing use; in a 16-week study it recovered after 4 weeks off. Always cycle off. Community practice — opinions vary. Not a clinical recommendation. - **Timing:** Fasted injection. 2–3x daily max. Watch for desensitisation signs. - **Route:** SubQ injection - **Stacks:** CJC-1295 no DAC, BPC-157 ## Safety. ### Common side effects - Cortisol elevation - Prolactin increase - Water retention - Fatigue - Desensitization with chronic use ## Goes with. - [CJC-1295 no DAC](https://pepvault.app/peptides/cjc-1295-no-dac) - [BPC-157](https://pepvault.app/peptides/bpc-157) ## Questions people ask. ### What is Hexarelin? One of the most powerful GH secretagogues, with a catch: the response fades. Hexarelin gives some of the largest GH spikes, but with daily use the response drops partly over weeks and recovers after a break. ### How is Hexarelin dosed in research? The research range for Hexarelin is 100–200 mcg, 2–3x daily. Studied in research — not a recommendation. ### How long does Hexarelin last? The half-life of Hexarelin is ~55–70 min (community estimate; not measured in people: in rats it lasted ~76 minutes, in dogs ~2 hours). ### What do people report on Hexarelin? Commonly reported on Hexarelin: A strong effect at first, flushing or a head rush after injecting, and water retention with some hunger (less than GHRP-6). In rats it also protected the heart through a pathway independent of GH. ### Is Hexarelin safe? The research basis for Hexarelin is moderate: animal studies + some human data. Common side effects in the library: cortisol elevation, prolactin increase, water retention, fatigue and desensitization with chronic use. ### What does Hexarelin stack with? Common stacks for Hexarelin: CJC-1295 no DAC and BPC-157. ## Research. The literature ### Search the latest research [PubMed](https://pubmed.ncbi.nlm.nih.gov/?term=Hexarelin) [Google Scholar](https://scholar.google.com/scholar?q=Hexarelin) ## Reference. - **Cadence:** 2–3× daily 2–3x daily - **Half-life:** ~55–70 min ~55–70 min (community estimate; not measured in people: in rats it lasted ~76 minutes, in dogs ~2 hours) - **Research basis:** Moderate Animal studies + some human data ## More growth hormone peptides - [MK-677 10–25 mg](https://pepvault.app/peptides/mk-677) - [Fragment 176-191 250–500 mcg](https://pepvault.app/peptides/fragment-176-191) - [IGF-1 LR3 20–50 mcg](https://pepvault.app/peptides/igf-1-lr3) - [PEG-MGF 200–400 mcg](https://pepvault.app/peptides/peg-mgf) - [Follistatin-344 100–200 mcg](https://pepvault.app/peptides/follistatin-344) - [HGH 1–4 IU](https://pepvault.app/peptides/hgh) ## Free tools - [Hexarelin dose guide](https://pepvault.app/lab/dosage/hexarelin) - [Reconstitution Lab (3D)](https://pepvault.app/lab) - [Injection guide (3D)](https://pepvault.app/lab/injection) - [Peptide Sky (3D)](https://pepvault.app/lab/sky) - [Peptide tier list](https://pepvault.app/lab/tiers) - [Reconstitution calculator](https://pepvault.app/tools/reconstitution-calculator) - [Half-life & active level](https://pepvault.app/tools/peptide-half-life-calculator) PepVault for iPhone ## Track Hexarelin in PepVault Log every dose, keep your vial and the doses left in it and watch its estimated active level. 7 days free on the yearly plan for new subscribers. [Download on the App Store](https://apps.apple.com/app/apple-store/id6779318649?pt=129020030&ct=peptides-cta&mt=8) [Open the calculator](https://pepvault.app/tools/reconstitution-calculator) [How the vial count works](https://pepvault.app/peptide-vial-tracker-app) [Explore the live demo](https://pepvault.app/login) Reviewed September 2026 [How we check the library](https://pepvault.app/about#library) PepVault is a research and tracking resource, not medical advice. Ranges are what studies used, never a dose for you. Brand names are trademarks of their owners; PepVault is independent of them. PepVault is a private research and tracking tool, not medical advice. The information here is reference material from published literature and community use — always verify it and discuss any protocol with a qualified clinician before changing it. © 2026 PepVault