# CJC-1295 with DAC vs CJC-1295 no DAC: How They Differ Source: https://pepvault.app/peptides/compare/cjc-1295-with-dac-vs-cjc-1295-no-dac Last updated: 2026-09-26 [Library](https://pepvault.app/peptides) [Comparisons](https://pepvault.app/peptides/compare) CJC-1295 with DAC vs CJC-1295 no DAC Compared side by side # CJC-1295 with DAC vs CJC-1295 no DAC: how they differ Reviewed September 2026 [How we check the library](https://pepvault.app/about#library) ## The short answer Both are GHRH analogues; the difference is the DAC (Drug Affinity Complex), which stretches CJC-1295’s half-life to about a week. With DAC, one weekly injection keeps GH and IGF-1 raised for days while natural pulses continue; without it (also sold as Mod GRF 1-29), the short action gives pulse-like GH release, taken 2–3 times a day. The no-DAC form is almost always stacked with ipamorelin. ## Side by side | Compared | [CJC-1295 with DAC](https://pepvault.app/peptides/cjc-1295-with-dac) | [CJC-1295 no DAC](https://pepvault.app/peptides/cjc-1295-no-dac) | | --- | --- | --- | | Category | Growth hormone | Growth hormone | | Also known as | CJC-1295 DAC, DAC:GRF | Modified GRF 1-29, Mod GRF 1-29, CJC-1295 without DAC | | What it is | A long-acting growth hormone releasing hormone analogue: the DAC modification extends its half-life to about a week, so one weekly injection keeps GH and IGF-1 raised, lifting baseline GH while natural pulses continue. | The shorter-acting version of CJC-1295, meant to give sharp, pulse-like GH release. | | How it works | GHRH analogue with Drug Affinity Complex that extends half-life to about a week. In human studies one injection raised baseline GH and IGF-1 for days while natural GH pulses continued; recovery, body-composition and sleep effects are extrapolated from GH physiology and user reports. Weekly dosing protocol. | GHRH analogue without the DAC modification. Its half-life in people hasn't been measured (native GHRH lasts minutes), and the short action gives pulse-like GH release. Usually stacked with Ipamorelin to mimic natural GH secretion patterns. | | Commonly reported | Water retention and puffiness, sometimes tingling hands, over the first weeks, and tiredness in the days after the shot. Its human data are two small phase 1 studies; it was never approved. | A flush or head rush within minutes of injecting, deeper sleep and vivid dreams early on, and mild water retention over the weeks. The no-DAC form itself has no published human studies. | | Studied range | Research range: 1–2 mg. Studied in research — not a recommendation. | Research range: 100–200 mcg. Studied in research — not a recommendation. | | How often | Weekly | 2–3x daily | | Half-life | ~6–8 days (measured in healthy adults: 5.8–8.1 days) | ~30 min (community estimate; not measured in people: sermorelin, the unmodified 1-29 chain, lasts 11–12 minutes) | | Route | SubQ injection | SubQ injection | | Typical run | 8–12 weeks common. Weekly dosing means effects accumulate — give adequate time off between cycles. | 8–12 weeks typical. Usually stacked with Ipamorelin; cycle both together. | | Evidence | Moderate: animal studies + some human data | Moderate: animal studies + some human data | | Common side effects | Water retention, headache, flushing, injection site pain, fatigue, carpal tunnel symptoms | Water retention, headache, flushing, injection site pain | Typical run: Community practice — opinions vary. Not a clinical recommendation. ## Week by week Each entry’s cards by day window, as the compound pages show them. Day 1 is the day you start it. ### CJC-1295 with DAC - Day 1–14 GH is building; water retention is common - Day 14–42 Recovery and skin quality are changing - Day 42–84 Peak recomp — watch for carpal tunnel [Every card for CJC-1295 with DAC, with its sources](https://pepvault.app/peptides/cjc-1295-with-dac#weeks) ### CJC-1295 no DAC - Day 1–14 Sleep usually moves first - Day 14–28 Recovery is quicker, skin looks better - Day 28–56 Body composition starts shifting - Day 56–84 Cycle endpoint [Every card for CJC-1295 no DAC, with its sources](https://pepvault.app/peptides/cjc-1295-no-dac#weeks) ## Questions people ask ### How long do CJC-1295 with DAC and CJC-1295 no DAC last? The half-life of CJC-1295 with DAC is ~6–8 days (measured in healthy adults: 5.8–8.1 days). The half-life of CJC-1295 no DAC is ~30 min (community estimate; not measured in people: sermorelin, the unmodified 1-29 chain, lasts 11–12 minutes). ### How often are CJC-1295 with DAC and CJC-1295 no DAC taken? CJC-1295 with DAC: weekly. Route: SubQ injection. CJC-1295 no DAC: 2–3x daily. Route: SubQ injection. ### How are CJC-1295 with DAC and CJC-1295 no DAC dosed in research? The research range for CJC-1295 with DAC is 1–2 mg. The research range for CJC-1295 no DAC is 100–200 mcg. Studied in research — not a recommendation. ### What are the common side effects of CJC-1295 with DAC and CJC-1295 no DAC? For CJC-1295 with DAC, the library lists: water retention, headache, flushing, injection site pain, fatigue, carpal tunnel symptoms. For CJC-1295 no DAC: water retention, headache, flushing, injection site pain. ## Each one in full - [CJC-1295 with DAC: dosage, half-life & reference guide](https://pepvault.app/peptides/cjc-1295-with-dac) - [CJC-1295 no DAC: dosage, half-life & reference guide](https://pepvault.app/peptides/cjc-1295-no-dac) - [CJC-1295 with DAC dose guide](https://pepvault.app/lab/dosage/cjc-1295-with-dac) - [CJC-1295 no DAC dose guide](https://pepvault.app/lab/dosage/cjc-1295-no-dac) PepVault for iPhone ## Track either one in PepVault Log every dose of CJC-1295 with DAC or CJC-1295 no DAC, with reminders on your schedule. 7 days free on the yearly plan for new subscribers. [Download on the App Store](https://apps.apple.com/app/apple-store/id6779318649?pt=129020030&ct=compound-vs-band&mt=8) [Explore the live demo](https://pepvault.app/login) ## More comparisons - [All peptide comparisons](https://pepvault.app/peptides/compare) - [CJC-1295 no DAC vs Ipamorelin](https://pepvault.app/peptides/compare/cjc-1295-no-dac-vs-ipamorelin) - [Retatrutide vs Tirzepatide](https://pepvault.app/peptides/compare/retatrutide-vs-tirzepatide) - [Semaglutide vs Tirzepatide](https://pepvault.app/peptides/compare/semaglutide-vs-tirzepatide) - [Retatrutide vs Semaglutide](https://pepvault.app/peptides/compare/retatrutide-vs-semaglutide) - [Mazdutide vs Tirzepatide](https://pepvault.app/peptides/compare/mazdutide-vs-tirzepatide) - [Survodutide vs Retatrutide](https://pepvault.app/peptides/compare/survodutide-vs-retatrutide) ## The library - [The peptide reference library](https://pepvault.app/peptides) - [Growth hormone peptides](https://pepvault.app/peptides#growth-hormone) ## Free tools - [The Dose Guide](https://pepvault.app/lab/dosage) - [Half-life & active level](https://pepvault.app/tools/peptide-half-life-calculator) - [Reconstitution calculator](https://pepvault.app/tools/reconstitution-calculator) PepVault is a research and tracking resource, not medical advice. Ranges are what studies used, never a dose for you. Brand names are trademarks of their owners; PepVault is independent of them. PepVault is a private research and tracking tool, not medical advice. The information here is reference material from published literature and community use — always verify it and discuss any protocol with a qualified clinician before changing it. © 2026 PepVault