# AOD-9604 vs Fragment 176-191: How They Differ | PepVault Source: https://pepvault.app/peptides/compare/aod-9604-vs-fragment-176-191 Last updated: 2026-09-26 [Library](https://pepvault.app/peptides) [Comparisons](https://pepvault.app/peptides/compare) AOD-9604 vs Fragment 176-191 Compared side by side # AOD-9604 vs Fragment 176-191: how they differ Reviewed September 2026 [How we check the library](https://pepvault.app/about#library) ## The short answer Fragment 176-191 is a stabilized fragment of growth hormone (amino acids 176-191), and it is usually the same peptide as AOD-9604, which is hGH 177-191 with an added tyrosine. In rodents both boosted the breakdown of stored fat without affecting blood sugar or IGF-1. In people, as AOD-9604, one 12-week trial found modest weight loss and a larger 24-week trial didn’t. ## Side by side | Compared | [AOD-9604](https://pepvault.app/peptides/aod-9604) | [Fragment 176-191](https://pepvault.app/peptides/fragment-176-191) | | --- | --- | --- | | Category | Healing & recovery | Growth hormone | | Also known as | Anti-Obesity Drug 9604, HGH Fragment 177-191 | HGH Fragment 176-191, HGH Frag, AOD Fragment | | What it is | A modified fragment of human growth hormone that targets fat metabolism. | A stabilized fragment of the growth hormone molecule (amino acids 176-191), usually sold as the same peptide as AOD-9604. | | How it works | Modified fragment of human growth hormone (HGH) that stimulates lipolysis and inhibits lipogenesis (shown in rat and mouse fat tissue) without affecting blood sugar or IGF-1. Cartilage repair was seen in one rabbit study. | Stabilized fragment of HGH amino acids 176-191, usually the same peptide as AOD-9604 (hGH 177-191 with an added tyrosine). Boosts fat breakdown (rodent studies) without affecting blood glucose or IGF-1 levels; in obese mice it raised beta-3 receptor levels rather than binding them directly. | | Commonly reported | Little noticeable effect for many users, slow fat loss for others when paired with diet and training, and mild injection-site redness. | Subtle at best, with many users noticing little and some describing slow fat loss with fasted morning dosing and a diet, plus mild injection-site redness. Human trials (as AOD-9604) found modest weight loss at best. | | Studied range | Research range: 250–300 mcg. Studied in research — not a recommendation. | Research range: 250–500 mcg. Studied in research — not a recommendation. | | How often | Daily, fasted | Daily, split into 2 doses, fasted | | Half-life | ~30 min | ~30 min | | Route | SubQ injection | SubQ injection | | Typical run | 12–16 weeks common. Diminishing returns reported beyond 16 weeks; cycling recommended. | 12–16 weeks. Often cycled alongside CJC/Ipa stack. Plateau reported; cycling advised. | | Evidence | Moderate: animal studies + some human data | Moderate: animal studies + some human data | | Common side effects | Injection site reaction, mild headache, nausea | Injection site reactions, generally well tolerated, mild flushing | Typical run: Community practice — opinions vary. Not a clinical recommendation. ## Week by week Each entry’s cards by day window, as the compound pages show them. Day 1 is the day you start it. ### AOD-9604 - Day 1–7 A quiet first week - Day 7–21 Subtle changes, for some users - Day 21–42 Body composition is shifting - Day 42–84 Judge it at week 12 [Every card for AOD-9604, with its sources](https://pepvault.app/peptides/aod-9604#weeks) ### Fragment 176-191 - Day 1–14 No GH effects to feel - Day 14–56 A slow drift, for some users - Day 56–112 Plateau is a real thing here [Every card for Fragment 176-191, with its sources](https://pepvault.app/peptides/fragment-176-191#weeks) ## Questions people ask ### How long do AOD-9604 and Fragment 176-191 last? The half-life of AOD-9604 is ~30 min. The half-life of Fragment 176-191 is ~30 min. ### How often are AOD-9604 and Fragment 176-191 taken? AOD-9604: daily, fasted. Route: SubQ injection. Fragment 176-191: daily, split into 2 doses, fasted. Route: SubQ injection. ### How are AOD-9604 and Fragment 176-191 dosed in research? The research range for AOD-9604 is 250–300 mcg. The research range for Fragment 176-191 is 250–500 mcg. Studied in research — not a recommendation. ### What are the common side effects of AOD-9604 and Fragment 176-191? For AOD-9604, the library lists: injection site reaction, mild headache, nausea. For Fragment 176-191: injection site reactions, generally well tolerated, mild flushing. ## Each one in full - [AOD-9604: dosage, half-life & reference guide](https://pepvault.app/peptides/aod-9604) - [Fragment 176-191: dosage, half-life & reference guide](https://pepvault.app/peptides/fragment-176-191) - [AOD-9604 dose guide](https://pepvault.app/lab/dosage/aod-9604) - [Fragment 176-191 dose guide](https://pepvault.app/lab/dosage/fragment-176-191) PepVault for iPhone ## Track either one in PepVault Log every dose of AOD-9604 or Fragment 176-191, with reminders on your schedule. 7 days free on the yearly plan for new subscribers. [Download on the App Store](https://apps.apple.com/app/apple-store/id6779318649?pt=129020030&ct=compound-vs-band&mt=8) [Explore the live demo](https://pepvault.app/login) ## More comparisons - [All peptide comparisons](https://pepvault.app/peptides/compare) - [Retatrutide vs Tirzepatide](https://pepvault.app/peptides/compare/retatrutide-vs-tirzepatide) - [Semaglutide vs Tirzepatide](https://pepvault.app/peptides/compare/semaglutide-vs-tirzepatide) - [Retatrutide vs Semaglutide](https://pepvault.app/peptides/compare/retatrutide-vs-semaglutide) - [Mazdutide vs Tirzepatide](https://pepvault.app/peptides/compare/mazdutide-vs-tirzepatide) - [Survodutide vs Retatrutide](https://pepvault.app/peptides/compare/survodutide-vs-retatrutide) - [Orforglipron vs Semaglutide](https://pepvault.app/peptides/compare/orforglipron-vs-semaglutide) ## The library - [The peptide reference library](https://pepvault.app/peptides) - [Healing & recovery peptides](https://pepvault.app/peptides#healing) - [Growth hormone peptides](https://pepvault.app/peptides#growth-hormone) ## Free tools - [The Dose Guide](https://pepvault.app/lab/dosage) - [Half-life & active level](https://pepvault.app/tools/peptide-half-life-calculator) - [Reconstitution calculator](https://pepvault.app/tools/reconstitution-calculator) PepVault is a research and tracking resource, not medical advice. Ranges are what studies used, never a dose for you. Brand names are trademarks of their owners; PepVault is independent of them. PepVault is a private research and tracking tool, not medical advice. The information here is reference material from published literature and community use — always verify it and discuss any protocol with a qualified clinician before changing it. © 2026 PepVault