# Peptide Comparisons, Side by Side | PepVault

Source: https://pepvault.app/peptides/compare

Last updated: 2026-10-12

[Library](https://pepvault.app/peptides) Comparisons

Peptide reference library

# Peptide comparisons, side by side

Two compounds at a time: how each works, its half-life, how often it’s taken, its studied range, side effects and evidence. Every fact comes from the same checked library entries as the compound pages.

Reviewed October 2026

## Healing & recovery

- [BPC-157 vs TB-500 BPC-157 is a peptide derived from a protective protein in human gastric juice; in animal studies it speeds the repair of tendons, ligaments, muscle and gut lining, partly by growing new blood vessels.](https://pepvault.app/peptides/compare/bpc-157-vs-tb-500)
- [KPV vs BPC-157 KPV is three amino acids from the tail end of α-MSH; in cell and mouse studies it enters cells and blocks NF-κB, the master switch for inflammatory signals.](https://pepvault.app/peptides/compare/kpv-vs-bpc-157)
- [GHK-Cu vs BPC-157 GHK-Cu is a copper-binding tripeptide found naturally in human plasma and widely used in skincare; in cell and animal studies it boosts collagen and speeds wound repair.](https://pepvault.app/peptides/compare/ghk-cu-vs-bpc-157)
- [TB-500 vs Thymosin Beta-4 Thymosin beta-4 is the whole protein; TB-500 is a 7-amino-acid fragment of it (residues 17–23), the stretch that binds actin.](https://pepvault.app/peptides/compare/tb-500-vs-thymosin-beta-4)
- [AOD-9604 vs Fragment 176-191 Fragment 176-191 is a stabilized fragment of growth hormone (amino acids 176-191), and it is usually the same peptide as AOD-9604, which is hGH 177-191 with an added tyrosine.](https://pepvault.app/peptides/compare/aod-9604-vs-fragment-176-191)

## Growth hormone

- [CJC-1295 no DAC vs Ipamorelin They raise growth hormone through different receptors: CJC-1295 no DAC is a GHRH analogue that amplifies each GH pulse, and ipamorelin is a ghrelin receptor agonist that triggers it, without raising cortisol in animal studies.](https://pepvault.app/peptides/compare/cjc-1295-no-dac-vs-ipamorelin)
- [CJC-1295 with DAC vs CJC-1295 no DAC Both are GHRH analogues; the difference is the DAC (Drug Affinity Complex), which stretches CJC-1295’s half-life to about a week.](https://pepvault.app/peptides/compare/cjc-1295-with-dac-vs-cjc-1295-no-dac)
- [Sermorelin vs Tesamorelin Both are synthetic GHRH analogues that stimulate the body’s own growth hormone release, and both are short-lived: about 11–12 minutes for sermorelin and 8–11 for tesamorelin.](https://pepvault.app/peptides/compare/sermorelin-vs-tesamorelin)
- [Ipamorelin vs Sermorelin Both prompt the pituitary to release its own growth hormone, through different receptors: sermorelin is a copy of the first 29 amino acids of GHRH, and ipamorelin is a ghrelin receptor agonist that released GH without raising cortisol in animal studies.](https://pepvault.app/peptides/compare/ipamorelin-vs-sermorelin)
- [Ipamorelin vs MK-677 Both raise growth hormone through the ghrelin receptor, but ipamorelin is injected 2–3 times a day, and MK-677 is a small molecule (not a peptide) taken by mouth once a day.](https://pepvault.app/peptides/compare/ipamorelin-vs-mk-677)

## Metabolic & GLP-1

- [Retatrutide vs Tirzepatide Tirzepatide is a dual GIP/GLP-1 receptor agonist; retatrutide adds a third target, the glucagon receptor, whose arm adds energy expenditure (shown so far in mice).](https://pepvault.app/peptides/compare/retatrutide-vs-tirzepatide)
- [Semaglutide vs Tirzepatide Semaglutide is a GLP-1 receptor agonist; tirzepatide activates the GLP-1 receptor and the GIP receptor too.](https://pepvault.app/peptides/compare/semaglutide-vs-tirzepatide)
- [Retatrutide vs Semaglutide Semaglutide activates one receptor, GLP-1; retatrutide activates three, GLP-1, GIP and glucagon, and its glucagon arm adds energy expenditure (shown so far in mice).](https://pepvault.app/peptides/compare/retatrutide-vs-semaglutide)
- [Mazdutide vs Tirzepatide Both are weekly dual agonists built around the GLP-1 receptor, and the second target differs: glucagon for mazdutide, GIP for tirzepatide.](https://pepvault.app/peptides/compare/mazdutide-vs-tirzepatide)
- [Survodutide vs Retatrutide Survodutide activates two receptors, GLP-1 and glucagon; retatrutide activates those two and GIP as well.](https://pepvault.app/peptides/compare/survodutide-vs-retatrutide)
- [Orforglipron vs Semaglutide Both act on the GLP-1 receptor, but orforglipron is a small molecule (not a peptide) taken as a daily tablet, with or without food, while semaglutide is given as a weekly shot.](https://pepvault.app/peptides/compare/orforglipron-vs-semaglutide)
- [Cagrilintide vs Semaglutide They act on different hormones: cagrilintide is a long-acting analogue of amylin, the fullness hormone the pancreas releases with insulin, and semaglutide is a GLP-1 receptor agonist.](https://pepvault.app/peptides/compare/cagrilintide-vs-semaglutide)
- [Liraglutide vs Semaglutide Both are GLP-1 receptor agonists, and liraglutide is semaglutide’s predecessor: its half-life of about 13 hours means a daily shot, where semaglutide’s of about a week allows one a week.](https://pepvault.app/peptides/compare/liraglutide-vs-semaglutide)

## Longevity

- [MOTS-c vs SS-31 Both work on mitochondria, from different sides: MOTS-c is a peptide encoded by mitochondrial DNA that, in mice, activates AMPK, the pathway exercise triggers; SS-31 binds cardiolipin in the inner mitochondrial membrane and, in cell and animal studies, cuts oxidative stress.](https://pepvault.app/peptides/compare/mots-c-vs-ss-31)

## Cognitive

- [Selank vs Semax Both are used as nasal sprays and approved in Russia, with opposite jobs: Selank, a tuftsin analogue, eased anxiety without sedation in small Russian trials, while Semax, derived from ACTH, raises BDNF in rats and is approved there for stroke recovery.](https://pepvault.app/peptides/compare/selank-vs-semax)

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PepVault is a private research and tracking tool, not medical advice. The information here is reference material from published literature and community use — always verify it and discuss any protocol with a qualified clinician before changing it.

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