# CJC-1295 with DAC — dosage, half-life & reference guide

Source: https://pepvault.app/peptides/cjc-1295-with-dac

Last updated: 2026-09-26

[Library](https://pepvault.app/peptides) [Growth hormone](https://pepvault.app/peptides#growth-hormone) reviewed September 2026

# CJC-1295 with DAC Dosage, half-life & reference guide

Also known as CJC-1295 DAC · DAC:GRF

A long-acting growth hormone releasing hormone analogue: the DAC modification extends its half-life to about a week, so one weekly injection keeps GH and IGF-1 raised, lifting baseline GH while natural pulses continue.

- **Studied range:** 1–2 mg
- **How often:** Weekly
- **Half-life:** ~6–8 days
- **Evidence:** Moderate
- **Route:** SubQ injection

Studied in research — not a recommendation.

[CJC-1295 with DAC dose guide](https://pepvault.app/lab/dosage/cjc-1295-with-dac)

## How it works.

GHRH analogue with Drug Affinity Complex that extends half-life to about a week. In human studies one injection raised baseline GH and IGF-1 for days while natural GH pulses continued; recovery, body-composition and sleep effects are extrapolated from GH physiology and user reports. Weekly dosing protocol.

**Commonly reported:** Water retention and puffiness, sometimes tingling hands, over the first weeks, and tiredness in the days after the shot. Its human data are two small phase 1 studies; it was never approved.

### Half-life & active level

The half-life of CJC-1295 with DAC is ~6–8 days (measured in healthy adults: 5.8–8.1 days).

Here's how a typical CJC-1295 with DAC schedule accumulates over four weeks (one-compartment estimate).

An estimate from the half-life above, not a measurement. See your own curve build live in [the half-life calculator](https://pepvault.app/tools/peptide-half-life-calculator).

## Where CJC-1295 with DAC works.

- ### Appetite & metabolism

  **Reported by users.** Commonly reported in this window: measurable fat loss and lean gains.
- ### Muscle

  **Reported by users.** Commonly reported: faster recovery, fuller-looking skin and a shift in body composition, with water retention usually settled by now.
- ### Energy & longevity

  **In people.** In human studies one injection raised baseline GH and IGF-1 for days while natural GH pulses continued.

An area lights for what a peptide is used for and what people report, with the evidence beside it. It isn’t a promise that it works there.

## Week by week.

What to expect in the first 8 weeks

- **Onset:** 1–3 weeks
- **Peak effect:** 8–12 weeks
- **Duration:** 8–12 weeks

1. Day 1–14 Clinical

   ### GH is building; water retention is common

   The DAC modification means one injection keeps GH raised for about a week. Commonly reported: water retention in the first couple of weeks (don't mistake it for fat gain) and deeper sleep.

   The science

   CJC-1295 DAC binds to serum albumin via the Drug Affinity Complex, giving a half-life of about 6–8 days. In phase 1 trials one injection raised IGF-1 1.5- to 3-fold for 9–11 days (Teichman 2006). The water retention is GH-mediated sodium retention in the kidneys, a common and usually transient effect.

   Sources

   - Teichman et al. (2006)

   Updated Sep 2026
2. Day 14–42 Community

   ### Recovery and skin quality are changing

   Weeks 2 to 6 are where the DAC variant's weekly convenience shows. Commonly reported: faster recovery, fuller-looking skin and a shift in body composition, with water retention usually settled by now.

   The science

   CJC-1295 DAC raised baseline (trough) GH about 7.5-fold while the frequency and size of natural GH pulses stayed the same (Ionescu 2006); that raised baseline drives the sustained IGF-1 rise. Body-composition effects haven't been measured in trials.

   Sources

   - Teichman et al. (2006)
   - Ionescu & Frohman (2006)

   Updated Sep 2026
3. Day 42–84 Clinical

   ### Peak recomp — watch for carpal tunnel

   Commonly reported in this window: measurable fat loss and lean gains. Watch for carpal tunnel symptoms (tingling or numbness in the hands), which come from GH-driven fluid retention around nerves, and raise them with your clinician if they appear.

   The science

   Fluid retention (swelling, joint pain, carpal tunnel) is the most common GH-related effect and eases with dose reduction or stopping. Glucose effects matter too, and FDA says it has identified serious adverse events with CJC-1295, including increased heart rate and systemic vasodilatory reactions. IGF-1 monitoring is advisable at 8+ weeks to ensure levels remain within a safe range.

   Sources

   - Teichman et al. (2006)

   Updated Sep 2026
4. Any day Clinical

   ### What CJC-1295 DAC is built on

   CJC-1295 has phase 1 data showing sustained GH and IGF-1 elevation; its phase 2 trial was stopped in 2006. Developed by ConjuChem, the DAC version is well characterized pharmacologically, and the weekly convenience is real. The community generally prefers the no-DAC variant for more pulse-like dosing.

   The science

   Teichman et al. (2006), two phase 1 trials in healthy adults: single ascending doses raised mean GH 2- to 10-fold for 6 days or more, and IGF-1 rose 1.5- to 3-fold for 9–11 days (up to 28 days with repeat doses). GH pulses stayed intact while baseline GH rose (Ionescu 2006). The phase 2 in HIV-associated abdominal fat was stopped in 2006 after a participant death judged unrelated, so no patient trial was completed.

   Sources

   - Teichman et al. (2006)
   - Ionescu & Frohman (2006)

   Updated Sep 2026

Day 1 is the day you start it.

Phase 1 trial data showing sustained GH/IGF-1 elevation (Teichman 2006). Body composition outcomes mainly community-reported.

Moderate evidence

## Mixing and a typical run.

Example numbers

### Reconstitution example

Reconstitute a 10 mg vial of CJC-1295 with DAC with 2 mL of bacteriostatic water and a 2 mg dose is 40 units on a U-100 syringe, about 5 doses per vial.

- **Vial:** 10 mg
- **Water:** 2 mL
- **Amount:** 2 mg

Draw to **40 units**

0.5 mL insulin syringe · 50 units

[Mix it in the Reconstitution Lab](https://pepvault.app/lab) [Open the calculator](https://pepvault.app/tools/reconstitution-calculator)

### Run notes

- **Cycle:** 8–12 weeks common. Weekly dosing means effects accumulate — give adequate time off between cycles. Community practice — opinions vary. Not a clinical recommendation.
- **Timing:** Once weekly SubQ. Day and time flexible — consistency matters more than specific timing.
- **Route:** SubQ injection
- **Stacks:** Ipamorelin, BPC-157

## Safety.

### Common side effects

- Water retention
- Headache
- Flushing
- Injection site pain
- Fatigue
- Carpal tunnel symptoms

## Goes with.

- [Ipamorelin](https://pepvault.app/peptides/ipamorelin)
- [BPC-157](https://pepvault.app/peptides/bpc-157)

## Compared with.

- [CJC-1295 with DAC vs CJC-1295 no DAC](https://pepvault.app/peptides/compare/cjc-1295-with-dac-vs-cjc-1295-no-dac)

## Questions people ask.

### What is CJC-1295 with DAC?

A long-acting growth hormone releasing hormone analogue: the DAC modification extends its half-life to about a week, so one weekly injection keeps GH and IGF-1 raised, lifting baseline GH while natural pulses continue.

### How is CJC-1295 with DAC dosed in research?

The research range for CJC-1295 with DAC is 1–2 mg, weekly. Studied in research — not a recommendation.

### How long does CJC-1295 with DAC last?

The half-life of CJC-1295 with DAC is ~6–8 days (measured in healthy adults: 5.8–8.1 days).

### What do people report on CJC-1295 with DAC?

Commonly reported on CJC-1295 with DAC: water retention and puffiness, sometimes tingling hands, over the first weeks, and tiredness in the days after the shot. Its human data are two small phase 1 studies; it was never approved.

### Is CJC-1295 with DAC safe?

The research basis for CJC-1295 with DAC is moderate: animal studies + some human data. Common side effects in the library: water retention, headache, flushing, injection site pain, fatigue and carpal tunnel symptoms.

### What does CJC-1295 with DAC stack with?

Common stacks for CJC-1295 with DAC: Ipamorelin and BPC-157.

## Research.

The literature

### Search the latest research

[PubMed](https://pubmed.ncbi.nlm.nih.gov/?term=CJC-1295%20with%20DAC) [Google Scholar](https://scholar.google.com/scholar?q=CJC-1295%20with%20DAC)

Guide

### [What to take alongside each peptide](https://pepvault.app/guides/what-to-take-with-peptides)

Read the guide

## Reference.

- **Cadence:** Weekly
- **Half-life:** ~6–8 days ~6–8 days (measured in healthy adults: 5.8–8.1 days)
- **Research basis:** Moderate Animal studies + some human data

## More growth hormone peptides

- [CJC-1295 no DAC 100–200 mcg](https://pepvault.app/peptides/cjc-1295-no-dac)
- [Sermorelin 200–500 mcg](https://pepvault.app/peptides/sermorelin)
- [Tesamorelin 1–2 mg](https://pepvault.app/peptides/tesamorelin)
- [GHRP-2 100–300 mcg](https://pepvault.app/peptides/ghrp-2)
- [GHRP-6 100–300 mcg](https://pepvault.app/peptides/ghrp-6)
- [Hexarelin 100–200 mcg](https://pepvault.app/peptides/hexarelin)

## Free tools

- [CJC-1295 with DAC dose guide](https://pepvault.app/lab/dosage/cjc-1295-with-dac)
- [Reconstitution Lab (3D)](https://pepvault.app/lab)
- [Injection guide (3D)](https://pepvault.app/lab/injection)
- [Peptide Sky (3D)](https://pepvault.app/lab/sky)
- [Peptide tier list](https://pepvault.app/lab/tiers)
- [Reconstitution calculator](https://pepvault.app/tools/reconstitution-calculator)
- [Half-life & active level](https://pepvault.app/tools/peptide-half-life-calculator)

PepVault for iPhone

## Track CJC-1295 with DAC in PepVault

Log every dose, keep your vial and the doses left in it and watch its estimated active level. 7 days free on the yearly plan for new subscribers.

[Download on the App Store](https://apps.apple.com/app/apple-store/id6779318649?pt=129020030&ct=peptides-cta&mt=8)

[Open the calculator](https://pepvault.app/tools/reconstitution-calculator) [How the vial count works](https://pepvault.app/peptide-vial-tracker-app) [Explore the live demo](https://pepvault.app/login)

Reviewed September 2026 [How we check the library](https://pepvault.app/about#library)

PepVault is a research and tracking resource, not medical advice. Ranges are what studies used, never a dose for you. Brand names are trademarks of their owners; PepVault is independent of them.

PepVault is a private research and tracking tool, not medical advice. The information here is reference material from published literature and community use — always verify it and discuss any protocol with a qualified clinician before changing it.

© 2026 PepVault